Seasonal affective disorder

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Seasonal affective disorder
Classification and external resources
Dark winter clouds
DiseasesDB 11910
MedlinePlus 001532
MeSH D016574

Seasonal affective disorder (SAD), also known as winter depression or winter blues, is a mood disorder in which people who have normal mental health throughout most of the year experience depressive symptoms in the winter or, less frequently, in the summer,[1] repeatedly, year after year. The US National Library of Medicine notes that "some people experience a serious mood change when the seasons change. They may sleep too much, have little energy, and crave sweets and starchy foods. They may also feel depressed. Though symptoms can be severe, they usually clear up."[2] The condition in the summer is often referred to as Reverse Seasonal Affective Disorder, and can also include heightened anxiety.[3]

There are many different treatments for classic (winter-based) seasonal affective disorder, including light therapies with bright lights, anti-depression medication, ionized-air administration,[4] cognitive-behavioral therapy, and carefully timed supplementation of the hormone melatonin.

Contents

[edit] Pathophysiology

Seasonal mood variations are believed to be related to light. An argument for this view is the effectiveness of bright-light therapy.[5] SAD is measurably present at latitudes in the Arctic region, such as Finland (64º 00´N) where the rate of SAD is 9.5%[6] Cloud cover may contribute to the negative effects of SAD.[7]

SAD can be a serious disorder and may require hospitalization. There is also potential risk of suicide in some patients experiencing SAD. One study reports 6-35% of sufferers required hospitalization during one period of illness.[7] The symptoms of SAD mimic those of dysthymia or clinical depression. At times, patients may not feel depressed, but rather lack energy to perform everyday activities.[5] Norman Rosenthal, a pioneer in SAD research, has estimated that the prevalence of SAD in the adult United States population is between about 1.5 percent in Florida and about 9 percent in the northern US.[7]

Various etiologies have been performed. One possibility is that SAD is related to a lack of serotonin, and serotonin polymorphisms could play a role in SAD,[8] although this has been disputed.[9] Mice incapable of turning serotonin into N-acetylserotonin (by Serotonin N-acetyltransferase) appear to express "depression-like" behavior, and antidepressants such as fluoxetine increase the amount of the enzyme Serotonin N-acetyltransferase, resulting in an antidepressant-like effect.[10] Another theory is that the cause may be related to melatonin which is produced in dim light and darkness by the pineal gland, since there are direct connections, via the retinohypothalamic tract and the suprachiasmatic nucleus, between the retina and the pineal gland.

Subsyndromal Seasonal Affective Disorder is a milder form of SAD experienced by an estimated 14.3% vs. 6.1% of the U.S. population.[11] The blue feeling experienced by both SAD and SSAD sufferers can usually be dampened or extinguished by exercise and increased outdoor activity, particularly on sunny days, resulting in increased solar exposure.[12] Connections between human mood, as well as energy levels, and the seasons are well documented, even in healthy individuals.

Mutation of a gene expressing melanopsin has been implicated in the risk of having Seasonal Affective Disorder.[13]

[edit] Diagnostic criteria

The Mayo Clinic[3] describes three types of Seasonal Affective Disorder, each with its own set of symptoms. According to the American Psychiatric Association DSM-IV,[14] criteria, Seasonal Affective disorder is not regarded as a separate disorder, rather it is termed a 'specifier' and may be applied as an added description to a Major Depressive Episode in patients with Major Depressive Disorder or patients with Bipolar Disorder. The Seasonal Pattern Specifier must meet four criteria: depressive episodes at a particular time of the year; remissions or mania/hypomania also at a characteristic time of year; these patterns must have lasted two years with no nonseasonal major depressive episodes during that same period; and these seasonal depressive episodes outnumber other depressive episodes throughout the patient's lifetime.

[edit] Treatment

Another type of light therapy lamp

There are many different treatments for classic (winter-based) seasonal affective disorder, including light therapies, medication, ionized-air administration, cognitive-behavioral therapy and carefully timed supplementation of the hormone melatonin.

Bright light treatment using a specially designed lamp, or light box, provides a much more intense illumination than traditional incandescent bulbs are capable of. The light is usually white "full spectrum", although blue light is also used. The light box has proven to be effective at doses of 2500 - 10,000 lux,[11] the sufferer sitting a prescribed distance, commonly 30-60 cm, in front of the box with her/his eyes open but not staring at the light source.[6] Most treatments use 30-60 minute treatments, however this may vary depending on the situation. Many patients use the light box in the morning, and there is evidence that morning light is superior to evening light, although people can respond to evening light as well.[15] Discovering the best schedule is essential. One study has shown that up to 69% of patients find the treatment inconvenient and as many as 19% stop use because of this.[6]

Dawn simulation has also proven to be effective; in some studies, there is an 83% better response when compared to other bright light therapy.[6] When compared in a study to negative air ionization, bright light was proven to be 57.1% effective vs. dawn simulation, 49.5%.[4] Patients using light therapy can experience improvement during the first week, but increased results are evident when continued throughout several weeks.[6] Most studies have found it effective without use year round, but rather as a seasonal treatment lasting for several weeks until frequent light exposure is naturally obtained.[5]

SSRI (selective serotonin reuptake inhibitor) antidepressants have proven effective in treating SAD. Bupropion is also effective as a prophylactic.[7] Effective antidepressants are fluoxetine, sertraline, or paroxetine.[5][16] Both fluoxetine and light therapy are 67% effective in treating SAD according to direct head-to-head trials conducted during the 2006 CAN-SAD study.[17] Subjects using the light therapy protocol showed earlier clinical improvement, generally within one week of beginning the clinical treatment.[5]

Negative air ionization, involving the release of charged particles into the sleep environment, has also been found effective with a 47.9% improvement.[4] Depending upon the patient, one treatment (ie. lightbox) may be used in conjunction with another therapy (ie. medication).[5] Modafinil may be also an effective and well-tolerated treatment in patients with seasonal affective disorder/winter depression.[18]

Alfred J. Lewy of Oregon Health and Science University in Portland, OHSU, and others see the cause of SAD as a misalignment of the sleep-wake phase contra the period of the body clock, circadian rhythms out of synch, and treat it with melatonin in the afternoon. Correctly timed melatonin administration shifts the rhythms of several hormones en bloc.[19]

[edit] Incidence

[edit] Nordic countries

Winter depression is a common slump in the mood of some inhabitants of most of the Nordic countries. It was first described by the 6th century Goth scholar Jordanes in his Getica wherein he described the inhabitants of Scandza (Scandinavia).[20] Iceland, however, seems to be an exception. A study of more than 2000 people there found the prevalence of seasonal affective disorder and seasonal changes in anxiety and depression to be unexpectedly low in both sexes.[21] The study's authors suggested that propensity for SAD may differ due to some genetic factor within the Icelandic population. A study of Canadians of wholly Icelandic descent also showed low levels of SAD.[22] It has more recently been suggested that this may be attributed to the large amount of fish traditionally eaten by Icelandic people, 225 lb per person per year as opposed to about 50 lb in the US and Canada, rather than to genetics.[23]

[edit] Other countries

In the United States, a diagnosis of seasonal affective disorder was first proposed by Norman E. Rosenthal, MD in 1984. Rosenthal wondered why he became sluggish during the winter after moving from sunny South Africa to New York. He started experimenting increasing exposure to artificial light, and found this made a difference. In Alaska it has been established that there is a SAD rate of 8.9%, and an even greater rate of 24.9%[24] for subsyndromal SAD. American science fiction-fantasy author Barbara Hambly had undiagnosed SAD for many years and speaks freely about her condition.[25]

Around 20% of Irish people are affected by SAD, according to a survey conducted in 2007. The survey also shows women are more likely to be affected by SAD than men. [26] An estimated 10% of the population in the Netherlands suffers from SAD. [27]

[edit] SAD and Bipolar

Most people with SAD experience major depressive disorder, but as many as 20% may have or may go on to develop a bipolar or manic-depressive disorder. It is important to discriminate the improved mood associated with recovery from the winter depression and a manic episode because there are important treatment differences.[28] In these cases, persons with SAD may experience depression during the winter and hypomania in the summer.

[edit] See also

[edit] References

  1. ^ Seasonal Depression can Accompany Summer Sun. Ivry, Sara. The New York Times. Retrieved September 6, 2008
  2. ^ U.S. National Library of Medicine
  3. ^ a b Seasonal Affective Disorder by Mayo Clinic
  4. ^ a b c Terman, M.; Terman, J.S. (2006). "Controlled Trial of Naturalistic Dawn Simulation and Negative Air Ionization for Seasonal Affective Disorder". American Journal of Psychiatry 163 (12): 2126–2133. doi:10.1176/appi.ajp.163.12.2126. 17151164. PMID 17151164. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17151164&query_hl=7&itool=pubmed_docsum. Retrieved on 2007-05-12. 
  5. ^ a b c d e f Lam, RW; Levitt AJ, Levitan RD, Enns MW, Morehouse R, Michalak EE, Tam EM (2006). "The Can-SAD Study: a randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder". American Journal of Psychiatry 163 (5): 805–812. doi:10.1176/appi.ajp.163.5.805. PMID 16648320. 
  6. ^ a b c d e Avery, D H; Eder DN, Bolte MA, Hellekson CJ, Dunner DL, Vitiello MV, Prinz PN (2001). "Dawn simulation and bright light in the treatment of SAD: a controlled study". Biological Psychiatry 50 (3): 205–216. doi:10.1016/S0006-3223(01)01200-8. PMID 11513820. 
  7. ^ a b c d Modell, Jack; Rosenthal NE, Harriett AE, Krishen A, Asgharian A, Foster VJ, Metz A, Rockett CB, Wightman DS (2005). Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL Biological Psychiatry. 58. pp. 658–667. PMID 16271314. 
  8. ^ Johansson, C; Smedh C, Partonen T, Pekkarinen P, Paunio T, Ekholm J, Peltonen L,Lichtermann D, Palmgren J, Adolfsson R, Schalling M (2001). "Seasonal affective disorder and serotonin-related polymorphisms". Neurobiology of Disease 8 (2): 351–357. doi:10.1006/nbdi.2000.0373. PMID 11300730. 
  9. ^ Johansson, C; Willeit M, Levitan R, Partonen T, Smedh C, Del Favero J, Bel Kacem S, Praschak-Rieder N,Neumeister A, Masellis M, Basile V, Zill P, Bondy B, Paunio T, Kasper S, Van Broeckhoven C, Nilsson LG,Lam R, Schalling M, Adolfsson R. (2003). "The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality". Psychological Medicine 33 (5): 785–792. doi:10.1017/S0033291703007372. PMID 12877393. 
  10. ^ Uz, T; Manev, H (2001). "Prolonged swim-test immobility of serotonin N-acetyltransferase (AANAT)-mutant mice". Journal of Pineal Research 30: 166–170. doi:10.1034/j.1600-079X.2001.300305.x. PMID 11316327. 
  11. ^ a b Avery, D. H.; Kizer D, Bolte MA, Hellekson C (2001). "Bright light therapy of subsyndromal seasonal affective disorder in the workplace: morning vs. afternoon exposure". Acta Psychiatrica Scandinavica 103 (4): 267–274. doi:10.1034/j.1600-0447.2001.00078.x. PMID 11328240. 
  12. ^ Leppämäki, Sami; Haukka J, Lonnqvist J, Partonen T (2004). "Drop-out and mood improvement: a randomised controlled trial with light exposure and physical exercise". BMC Psychiatry 4 (22): 22. doi:10.1186/1471-244X-4-22. PMID 15306031. 
  13. ^ "Breakthroughs tips and trends: November 7th - Times Online". www.timesonline.co.uk. http://www.timesonline.co.uk/tol/life_and_style/health/article5106718.ece. Retrieved on 2008-11-10. 
  14. ^ Gabbard, Glen O. Treatment of Psychiatric Disorders (Third edition, Volume 2 ed.). Washington, DC: American Psychiatric Publishing. pp. 1296. 
  15. ^ http://www.cochrane.org/reviews/en/ab004050.html
  16. ^ Moscovitch, A; Blashko CA, Eagles JM, Darcourt G, Thompson C, Kasper S, Lane RM (2004). "A placebo-controlled study of sertraline in the treatment of outpatients with seasonal affective disorder". Psychopharmacology 171: 390–397. doi:10.1007/s00213-003-1594-8. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14504682&query_hl=3&itool=pubmed_docsum. Retrieved on 2007-05-12. 
  17. ^ Lam, Raymond W.; Anthony J. Levitt, Robert D. Levitan, et al (May 2006). "The Can-SAD Study: A Randomized Controlled Trial of the Effectiveness of Light Therapy and Fluoxetine in Patients With Winter Seasonal Affective Disorder" (PDF, full text). Am J Psychiatry (163): 805–812. http://day-lights.com/light-therapy-news/downloads/can-sad-study-wp.pdf. Retrieved on 2008-09-30. 
  18. ^ Modafinil treatment in patients with seasonal affective disorder/winter depression: an open-label pilot study, Journal of affective disorders, 2004 Aug;81(2):173-8.
  19. ^ Bhattacharjee, Yudhijit (14 September 2007). "Is Internal Timing Key to Mental Health?" (PDF). ScienceMag (AAAS) 317: 1488–90. http://www.ohsu.edu/ohsuedu/academic/som/images/Al-Lewy-Science.pdf. Retrieved on 2008-02-18. 
  20. ^ Jordanes, Getica, ed. Mommsen, Mon. Germanae historica, V, Berlin, 1882.
  21. ^ Magnusson, Andres; Axelsson, Johann; Karlsson, Mikael M.; Oskarsson, Högni (February 2000). "Lack of Seasonal Mood Change in the Icelandic Population: Results of a Cross-Sectional Study". Am J Psychiatry (American Psychiatric Association) 157: 234–238. doi:10.1176/appi.ajp.157.2.234. PMID 10671392. http://ajp.psychiatryonline.org/cgi/content/full/157/2/234. Retrieved on 2007-11-27. 
  22. ^ Magnússon A, Axelsson J (1993). "The prevalence of seasonal affective disorder is low among descendants of Icelandic emigrants in Canada". Arch. Gen. Psychiatry 50 (12): 947–51. PMID 8250680. 
  23. ^ Cott, Jerry; Joseph R. Hibbeln (February 2001). "Lack of Seasonal Mood Change in Icelanders" (Letter to the Editor). Am J Psychiatry (American Psychiatric Association) 158 (158): 328. http://ajp.psychiatryonline.org/cgi/content/full/158/2/328. Retrieved on 2008-09-02. "Thus, high levels of fish consumption should be considered a potential etiology for the finding of a lack of seasonal affective disorder among the Icelandic population.". 
  24. ^ Seasonal Affective Disorder and Latitude
  25. ^ [ http://www.andromedaspaceways.com/inter_0002.htm Andromeda Spaceways interview with Barbara Hambly, discusses SAD]
  26. ^ BreakingNews.ie - One in five suffers from SAD
  27. ^ Elsevier - Dark Days: Winter Depression (in Dutch, easy to translate to English with google translate (or anything like that)
  28. ^ SAD and depression

[edit] External links

Retrieved from "http://en.wikipedia.org/wiki/Seasonal_affective_disorder"
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