Garlic

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Garlic
Allium sativum, known as garlic, from William Woodville, Medical Botany, 1793.
Allium sativum, known as garlic, from William Woodville, Medical Botany, 1793.
Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Monocots
Order: Asparagales
Family: Alliaceae
Subfamily: Allioideae
Tribe: Allieae
Genus: Allium
Species: A. sativum
Binomial name
Allium sativum
L.

Allium sativum L., commonly known as garlic, is a species in the onion family Alliaceae. Its close relatives include the onion, shallot, leek, and chive. Garlic has been used throughout recorded history for both culinary and medicinal purposes. It has a characteristic pungent, spicy flavor that mellows and sweetens considerably with cooking.[1] A bulb of garlic, the most commonly used part of the plant, is divided into numerous fleshy sections called cloves. Single clove garlic (also called Pearl garlic or Solo garlic) also exists -- it originates in the Yunnan province of China. The cloves are used as seed, for consumption (raw or cooked), and for medicinal purposes. The leaves, stems (scape), and flowers (bulbils) on the head (spathe) are also edible and are most often consumed while immature and still tender. The papery, protective layers of "skin" over various parts of the plant and the roots attached to the bulb are the only parts not considered palatable.

Contents

[edit] Origin and distribution

The ancestry of cultivated garlic, according to Zohary and Hopf, is not definitely established: "A difficulty in the identification of its wild progenitor is the sterility of the cultivars."[2]

Allium sativum grows in the wild in areas where it has become naturalised; it probably descended from the species Allium longicuspis, which grows wild in southwestern Asia.[3] The "wild garlic," "crow garlic," and "field garlic" of Britain are the species Allium ursinum, Allium vineale, and Allium oleraceum, respectively. In North America, Allium vineale (known as "wild garlic" or "crow garlic") and Allium canadense, known as "meadow garlic" or "wild garlic" and "wild onion," are common weeds in fields.[4] One of the best-known "garlics," the so-called elephant garlic, is actually a wild leek (Allium ampeloprasum).

[edit] Cultivation

Garlic is easy to grow and can be grown year-round in mild climates. In cold climates, cloves can be planted in the ground about six weeks before the soil freezes and harvested in late spring. Garlic plants are not attacked by pests. They can suffer from pink root, a disease that stunts the roots and turns them pink or red. Garlic plants can be grown close together, leaving enough room for the bulbs to mature, and are easily grown in containers of sufficient depth.

There are different types or subspecies of garlic, most notably hardneck garlic and softneck garlic. It is important to get the right kind of garlic for your latitude, as garlic can be day-length sensitive. Hardneck garlic is generally grown in cooler climates; softneck garlic is generally grown closer to the equator.[citation needed]

[edit] Production trends

Garlic output in 2005.

Garlic is grown globally, but China is by far the largest producer of garlic, with approximately 10.5 billion kilograms (23 billion pounds) annually, accounting for over 77% of world output. India (4.1%) and South Korea (2%) follow, with Russia (1.6%) in fourth place and the United States (where garlic is grown primarily as a cash crop in every state except for Alaska) in fifth place (1.4%).[2] This leaves 16% of global garlic production in countries that each produce less than 2% of global output. Much of the garlic production in the United States is centered on Gilroy, California, which calls itself the "garlic capital of the world."



Top Ten Garlic Producers — 11 June 2008
Country Production (Tonnes) Footnote
 People's Republic of China 12,088,000 F
 India 645,000 F
 South Korea 325,000 F
 Russia 254,000 F
 United States 221,810
 Egypt 168,000 F
 Spain 142,400
 Argentina 140,000 F
 Myanmar 128,000 F
 Ukraine 125,000 F
 World 15,686,310 A
No symbol = official figure, P = official figure, F = FAO estimate, * = unofficial/semiofficial/mirror data,
C = calculated figure, A = aggregate (may include official, semiofficial, or estimates).

Source: Food And Agricultural Organization of United Nations: Economic and Social Department: The Statistical Division

[edit] Uses

[edit] Culinary uses

Garlic being crushed using a garlic press.

Garlic is widely used around the world for its pungent flavor as a seasoning or condiment. It is a fundamental component in many or most dishes of various regions, including eastern Asia, south Asia, Southeast Asia, the Middle East, northern Africa, southern Europe, and parts of South and Central America. The flavour varies in intensity and aroma with the different cooking methods. It is often paired with onion, tomato, or ginger. The parchment-like skin is much like the skin of an onion and is typically removed before using in raw or cooked form. An alternative is to cut the top off the bulb, coat the cloves by dribbling olive oil (or other oil-based seasoning) over them, and roast them in an oven. The garlic softens and can be extracted from the cloves by squeezing the (root) end of the bulb, or individually by squeezing one end of the clove. In Japan and Korea, heads of garlic are fermented at high temperature; the resulting product, called black garlic, is sweet and syrupy, and is now being sold in the United States also.

Oils are often flavored with garlic cloves. Commercially prepared oils are widely available, but when preparing garlic-infused oil at home, there is a risk of botulism if the product is not stored properly. To reduce this risk, the oil should be refrigerated and used within one week. Manufacturers add acids and/or other chemicals to eliminate the risk of botulism in their products.[5]

In some cuisine, the young bulbs are pickled for 3–6 weeks in a mixture of sugar, salt, and spices. In eastern Europe, the shoots are pickled and eaten as an appetizer.

Immature scapes are tender and edible. They are also known as "garlic spears," "stems," or "tops." Scapes generally have a milder taste than cloves. They are often used in stir frying or prepared like asparagus. Garlic leaves are a popular vegetable in many parts of Asia. The leaves are cut, cleaned, and then stir-fried with eggs, meat, or vegetables.

Mixing garlic with eggs and olive oil produces aioli. Garlic, oil, and a chunky base produce skordalia. Blending garlic, almond, oil, and soaked bread produces ajoblanco.

About 1/4 teaspoon of dried powdered garlic is equivalent to one fresh clove.

[edit] Storage

Ready peeled garlic cloves sold in a plastic pot

Domestically, garlic is stored warm (above 18°C [64°F]) and dry to keep it dormant (so that it does not sprout). It is traditionally hung; softneck varieties are often braided in strands, called "plaits" or grappes. Garlic is often kept in oil to produce flavoured oil; however, the practice requires measures to be taken to prevent the garlic from spoiling. Untreated garlic kept in oil can support the growth of deadly Clostridium botulinum. Refrigeration will not assure the safety of garlic kept in oil. Peeled cloves may be stored in wine or vinegar in the refrigerator.[6]

Commercially, garlic is stored at −3°C, also dry.[7][8]

[edit] Historical use

Garlic has been used as both food and medicine in many cultures for thousands of years, dating at least as far back as the time that the Giza pyramids were built. It formed part of the diet of the Israelites in Egypt (Numbers 11:5) and of the labourers employed by Khufu in constructing his pyramid. Garlic is still grown in Egypt, but the Syrian variety is the kind most esteemed now (see Rawlinson's Herodotus, 2.125).

It was consumed by ancient Greek and Roman soldiers, sailors, and rural classes (Virgil, Ecologues ii. 11), and, according to Pliny the Elder (Natural History xix. 32), by the African peasantry. Galen eulogizes it as the "rustic's theriac" (cure-all) (see F. Adams' Paulus Aegineta, p. 99), and Alexander Neckam, a writer of the 12th century (see Wright's edition of his works, p. 473, 1863), recommends it as a palliative for the heat of the sun in field labor.

In the account of Korea's establishment as a nation, gods were said to have given mortal women with bear and tiger temperaments an immortal's black garlic before mating with them. This is a genetically unique six-clove garlic that was to have given the women supernatural powers and immortality. This garlic is still cultivated in a few mountain areas today.

In his Natural History, Pliny gives an exceedingly long list of scenarios in which it was considered beneficial (N.H. xx. 23). Dr. T. Sydenham valued it as an application in confluent smallpox, and, says Cullen (Mat. Med. ii. p. 174, 1789), found some dropsies cured by it alone. Early in the 20th century, it was sometimes used in the treatment of pulmonary tuberculosis or phthisis.

Harvesting garlic, from Tacuinum sanitatis, 15th century (Bibliothèque nationale).

Garlic was rare in traditional English cuisine (though it is said to have been grown in England before 1548) and has been a much more common ingredient in Mediterranean Europe. Garlic was placed by the ancient Greeks on the piles of stones at crossroads, as a supper for Hecate (Theophrastus, Characters, The Superstitious Man); and according to Pliny, garlic and onions were invoked as deities by the Egyptians at the taking of oaths. (Pliny also states that garlic demagnetizes lodestones, which is not factual.)[9] The inhabitants of Pelusium, in lower Egypt (who worshiped the onion), are said to have had an aversion to both onions and garlic as food.

To prevent the plant from running to leaf, Pliny (N.H. xix. 34) advised bending the stalk downward and covering with earth; seeding, he observes, may be prevented by twisting the stalk (by "seeding," he most likely meant the development of small, less potent bulbs).

[edit] Medicinal use and health benefits

Garlic, raw
Nutritional value per 100 g (3.5 oz)
Energy 150 kcal   620 kJ
Carbohydrates     33.06 g
- Sugars  1.00g
- Dietary fiber  2.1 g  
Fat 0.5 g
Protein 6.39 g
- β-carotene  5 μg  0%
Thiamine (Vit. B1)  0.2 mg   15%
Riboflavin (Vit. B2)  0.11 mg   7%
Niacin (Vit. B3)  0.7 mg   5%
Pantothenic acid (B5)  0.596 mg  12%
Vitamin B6  1.235 mg 95%
Folate (Vit. B9)  3 μg  1%
Vitamin C  31.2 mg 52%
Calcium  181 mg 18%
Iron  1.7 mg 14%
Magnesium  25 mg 7% 
Phosphorus  153 mg 22%
Potassium  401 mg   9%
Sodium  17 mg 1%
Zinc  1.16 mg 12%
Manganese 1.672 mg
Selenium 14.2 mcg
Percentages are relative to US
recommendations for adults.
Source: USDA Nutrient database

Garlic is claimed to help prevent heart disease (including atherosclerosis, high cholesterol, and high blood pressure) and cancer.[10] Animal studies, and some early investigational studies in humans, have suggested possible cardiovascular benefits of garlic. A Czech study found that garlic supplementation reduced accumulation of cholesterol on the vascular walls of animals.[11] Another study had similar results, with garlic supplementation significantly reducing aortic plaque deposits of cholesterol-fed rabbits.[12] Another study showed that supplementation with garlic extract inhibited vascular calcification in human patients with high blood cholesterol.[13] The known vasodilative effect of garlic is possibly caused by catabolism of garlic-derived polysulfides to hydrogen sulfide in red blood cells, a reaction that is dependent on reduced thiols in or on the RBC membrane. Hydrogen sulfide is an endogenous cardioprotective vascular cell-signaling molecule.[14]

However, a randomized clinical trial funded by the National Institutes of Health (NIH) in the United States and published in the Archives of Internal Medicine in 2007 found that the consumption of garlic in any form did not reduce blood cholesterol levels in patients with moderately high baseline cholesterol levels.[15][16]

Despite decades of research suggesting that garlic can improve cholesterol profiles, a new NIH-funded trial found absolutely no effects of raw garlic or garlic supplements on LDL, HDL, or triglycerides… The findings underscore the hazards of meta-analyses made up of small, flawed studies and the value of rigorously studying popular herbal remedies.

—theheart.org, 2007-02-26[17]

In 2007, the BBC reported that Allium sativum may have beneficial properties, such as preventing and fighting the common cold.[18] This assertion has the backing of long tradition in herbal medicine, which has used garlic for hoarseness and coughs.[19] The Cherokee also used it as an expectorant for coughs and croup.[20]

Allium sativum has been found to reduce platelet aggregation[21][22][23][24] and hyperlipidemia.[24][25][26]

Garlic is also alleged to help regulate blood sugar levels. Regular and prolonged use of therapeutic amounts of aged garlic extracts lower blood homocysteine levels and has shown to prevent some complications of diabetes mellitus.[27][28] People taking insulin should not consume medicinal amounts of garlic without consulting a physician.

In 1858, Louis Pasteur observed garlic's antibacterial activity, and it was used as an antiseptic to prevent gangrene during World War I and World War II.[29] More recently, it has been found from a clinical trial that a mouthwash containing 2.5% fresh garlic shows good antimicrobial activity, although the majority of the participants reported an unpleasant taste and halitosis.[30]

In modern naturopathy, garlic is used as a treatment for intestinal worms and other intestinal parasites, both orally and as an anal suppository. Garlic cloves are used as a remedy for infections (especially chest problems), digestive disorders, and fungal infections such as thrush.[3][4]

Garlic has been used reasonably successfully in AIDS patients to treat cryptosporidium in an uncontrolled study in China.[31] It has also been used by at least one AIDS patient to treat toxoplasmosis, another protozoal disease.[32]

Garlic supplementation in rats, along with a high protein diet, has been shown to boost testosterone levels.[33]

[edit] Side effects

Garlic is known for causing halitosis as well as causing sweat to have a pungent 'garlicky' smell which is caused by Allyl methyl sulfide (AMS). AMS is a gas which is absorbed into the blood during the metabolism of garlic, from the blood it travels to the lungs (and from there to the mouth causing bad breath) and skin where it is exuded through skin pores, washing the skin with soap is only a partial and imperfect solution to the smell. Raw garlic is more potent and therefore cooking garlic reduces the effect. The green dry 'folds' in the center of the garlic clove are especially pungent.

[edit] Properties

When crushed, Allium sativum yields allicin, a powerful antibiotic and antifungal compound (phytoncide). In some cases, it can be used as a home remedy to help speed recovery from strep throat or other minor ailments because of its antibiotic properties. It also contains the sulfur containing compounds alliin, ajoene, diallylsulfide, dithiin, S-allylcysteine, and enzymes, vitamin B, proteins, minerals, saponins, flavonoids, and maillard reaction products, which are non-sulfur containing compounds. Furthermore a phytoalexin called allixin (3-hydroxy-5-methoxy-6-methyl-2-penthyl-4H-pyran-4-one) was found, a non-sulfur compound with a γ-pyrone skeleton structure with anti-oxidative effects,[1] anti-microbial effects,[34] anti-tumor promoting effects,[35] inhibition of aflatoxin B2 DNA binding,[36] and neurotrophic effects.[4] Allixin showed an anti-tumor promoting effect in vivo, inhibiting skin tumor formation by TPA in DMBA initiated mice.[37] Analogs of this compound have exhibited anti tumor promoting effects in in vitro experimental conditions.[5] Herein, allixin and/or its analogs may be expected useful compounds for cancer prevention or chemotherapy agents for other diseases.

The composition of the bulbs is approximately 84.09% water, 13.38% organic matter, and 1.53% inorganic matter, while the leaves are 87.14% water, 11.27% organic matter, and 1.59% inorganic matter.[citation needed]

The phytochemicals responsible for the sharp flavor of garlic are produced when the plant's cells are damaged. When a cell is broken by chopping, chewing, or crushing, enzymes stored in cell vacuoles trigger the breakdown of several sulfur-containing compounds stored in the cell fluids. The resultant compounds are responsible for the sharp or hot taste and strong smell of garlic. Some of the compounds are unstable and continue to evolve over time. Among the members of the onion family, garlic has by far the highest concentrations of initial reaction products, making garlic much more potent than onions, shallots, or leeks.[38] Although people have come to enjoy the taste of garlic, these compounds are believed to have evolved as a defensive mechanism, deterring animals like birds, insects, and worms from eating the plant. Humans, however, usually enjoy these sensations for some reason.[39]

A large number of sulfur compounds contribute to the smell and taste of garlic. Diallyl disulfide is believed to be an important odour component. Allicin has been found to be the compound most responsible for the "hot" sensation of raw garlic. This chemical opens thermoTRP (transient receptor potential) channels that are responsible for the burning sense of heat in foods. The process of cooking garlic removes allicin, thus mellowing its spiciness.[40]

When eaten in quantity, garlic may be strongly evident in the diner's sweat and breath the following day. This is because garlic's strong-smelling sulfur compounds are metabolized, forming allyl methyl sulfide. Allyl methyl sulfide (AMS) cannot be digested and is passed into the blood. It is carried to the lungs and the skin, where it is excreted. Since digestion takes several hours, and release of AMS several hours more, the effect of eating garlic may be present for a long time.

This well-known phenomenon of "garlic breath" is alleged to be alleviated by eating fresh parsley. The herb is, therefore, included in many garlic recipes, such as Pistou, Persillade, and the garlic butter spread used in garlic bread. However, since the odour results mainly from digestive processes placing compounds such as AMS in the blood, and AMS is then released through the lungs over the course of many hours, eating parsley provides only a temporary masking. One way of accelerating the release of AMS from the body is the use of a sauna. Due to its strong odor, garlic is sometimes called the "stinking rose."

Because of the AMS in the bloodstream, it is believed by some to act as a mosquito repellent. However, there is no evidence to suggest that garlic is actually effective for this purpose.[41]

[edit] Spiritual and religious perceptions

Garlic has been regarded as a force for both good and evil. A Christian myth considers that after Satan left the Garden of Eden, garlic arose in his left footprint and onion in the right.[42] In Europe, many cultures have used garlic for protection or white magic, perhaps owing to its reputation as a potent preventative medicine.[43] Central European folk beliefs considered garlic a powerful ward against demons, werewolves, and vampires.[43] To ward off vampires, garlic could be worn, hung in windows, or rubbed on chimneys and keyholes.[44]

In Taoism mythology, six-clove black garlic is used as part of the process of modifying a Taoist's genetics. It supposedly endows the users immortality by intensifying their vital energy or "chi."[citation needed]

The association of garlic to evil spirits may be based on the antibacterial, antiparasitic value of garlic, which could prevent infections that lead to delusions and other related mental illness symptoms.[45][46]

In both Hinduism and Jainism, garlic is considered to stimulate and warm the body and to increase one's desires. Hindus generally avoid using garlic and the related onion in the preparation of foods for religious festivities and events. Followers of the Jain religion avoid eating garlic and onion on a daily basis.

In connection with the odor associated with garlic, Islam views eating garlic and subsequently going to the mosque as inappropriate. "Whoever has eaten (garlic) should not approach our mosque," indicated Muhammad.[47]

[edit] Cautions

  • Known adverse effects of garlic include halitosis (nonbacterial bad breath), indigestion, nausea, emesis, and diarrhea.[48]
  • Garlic may interact with warfarin, antiplatelets, saquinavir, antihypertensives, calcium channel blockers, and hypoglycemic drugs, as well as other medications. Consult a health professional before taking a garlic supplement[48] or consuming excessive amounts of garlic.
  • Garlic can thin the blood, similar to the effect of aspirin.[49]
  • Two outbreaks of botulism have been caused by consuming commercially produced garlic-in-oil preparations that were not properly preserved. It is especially important for home preparation to use safe and tested food preservation methods to retard bacterial growth, such as including sufficient salt or acidity and keeping the mixture refrigerated. It is recommended to not keep home preparations for more than a week.[50][51]
  • While culinary quantities are considered safe for consumption, very high quantities of garlic and garlic supplements have been linked with an increased risk of bleeding, particularly during pregnancy and after surgery and childbirth.[48][52] Some breastfeeding mothers have found their babies slow to feed and have noted a garlic odour coming from their baby when they have consumed garlic.[48][53] The safety of garlic supplements had not been determined for children.[53]
  • The side effects of long-term garlic supplementation, if any exist, are largely unknown, and no FDA-approved study has been performed. However, garlic has been consumed for several thousand years without any adverse long-term effects, suggesting that modest quantities of garlic pose, at worst, minimal risks to normal individuals. Possible side effects include gastrointestinal discomfort, sweating, dizziness, allergic reactions, bleeding, and menstrual irregularities.[52]
  • Some degree of liver toxicity has been demonstrated in rats, particularly in extremely large quantities exceeding those that a rat would consume under normal situations.[54]
  • There have been several reports of serious burns resulting from garlic being applied topically for various purposes, including naturopathic uses and acne treatment, so care must be taken to test a small area of skin using a very low concentration of garlic.[55] On the basis of numerous reports of such burns, including burns to children, topical use of raw garlic, as well as insertion of raw garlic into body cavities, is discouraged. In particular, topical application of raw garlic to young children is not advisable.[56]
  • Garlic and onions might be toxic to cats or dogs.[57]

[edit] References

[edit] Notes

  1. ^ Gernot Katzer (2005-02-23). "Spice Pages: Garlic (Allium sativum, garlick)". http://www.uni-graz.at/~katzer/engl/Alli_sat.html. Retrieved on 2007-08-28. 
  2. ^ Daniel Zohary and Maria Hopf, Domestication of plants in the Old World, third edition (Oxford: University Press, 2000), p. 197
  3. ^ Salunkhe and Kadam p. 397
  4. ^ McGee p. 112
  5. ^ It's Your Health - Garlic-In-Oil
  6. ^ GARLIC: Safe Methods to Store, Preserve and Enjoy
  7. ^ Garlic Produce Facts
  8. ^ Garlic Information: Storage
  9. ^ Lehoux, Daryn (2003). "Tropes, Facts, and Empiricism" (PDF). Perspectives on Science 11: 326–345. doi:10.1162/106361403773062678. http://personalpages.manchester.ac.uk/staff/daryn.lehoux/Tropes.pdf. 
  10. ^ University of Maryland Garlic
  11. ^ Sovova M, Sova P. Pharmaceutical importance of Allium sativum L. 5. Hypolipemic effects in vitro and in vivo. Ceska Slov Farm. 2004 May;53(3):117-23.]
  12. ^ Durak A, Ozturk HS, Olcay E, Guven C. Effects of garlic extract supplementation on blood lipid and antioxidant parameters and atherosclerotic plaque formation process of cholesterol-fed rabbits. J Herb Pharmcother. 2002;2(2):19-32.
  13. ^ Durak I, Kavutcu M, Aytac B, et al. Effects of garlic extract consumption on blood lipid and oxidant/antioxidant parameters in humans with high blood cholesterol. J Nutr Biochem. 2004 Jun;15(6):373-7.
  14. ^ Hydrogen sulfide mediates the vasoactivity of garlic.
  15. ^ Garlic - What We Know and What We Don't Know Retrieved 27 February 2007
  16. ^ Effect of Raw Garlic vs Commercial Garlic Supplements on Plasma Lipid Concentrations in Adults With Moderate Hypercholesterolemia - A Randomized Clinical Trial Retrieved 26 February 2007
  17. ^ Goodbye, garlic? Randomized controlled trial of raw garlic and supplements finds no effect on lipids Retrieved 27 February 2007
  18. ^ Garlic 'prevents common cold' 2007
  19. ^ Grieve, Maud. (Mrs.). Garlic. A Modern Herbal. Hypertext version of the 1931 edition. Accessed: December 18, 2006. [1]
  20. ^ Hamel, Paul B. and Mary U. Chiltoskey 1975 Cherokee Plants and Their Uses -- A 400 Year History. Sylva, N.C. Herald Publishing Co. (p. 35)
  21. ^ Rahman K (2007). "Effects of garlic on platelet biochemistry and physiology". Mol Nutr Food Res Nov;51 (11): 1335–44. doi:10.1002/mnfr.200700058. PMID 17966136. 
  22. ^ Chan KC, Yin MC, Chao WJ (2007). "Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats". Food Chem Toxicol Mar;45 (3): 502–7. PMID 17123684. 
  23. ^ Borrelli F, Capasso R, Izzo AA (2007). "Garlic (Allium sativum L.): adverse effects and drug interactions in humans". Mol Nutr Food Res Nov;51 (11): 1386–97. doi:10.1002/mnfr.200700072. PMID 17918162. 
  24. ^ a b Steiner M, Lin RS (1998). "Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract". J Cardiovasc Pharmacol Jun;31 (6):): 904–8. doi:10.1097/00005344-199806000-00014. PMID 9641475. 
  25. ^ Kojuri J, Vosoughi AR, Akrami M (2007). "Effects of anethum graveolens and garlic on lipid profile in hyperlipidemic patients". Lipids Health Dis Mar 1 (6): 5. doi:10.1186/1476-511X-6-5. PMID 17328819. 
  26. ^ Mader FH (1990). "Treatment of hyperlipidaemia with garlic-powder tablets. Evidence from the German Association of General Practitioners' multicentric placebo-controlled double-blind study". Arzneimittelforschung Oct;40 (10): 1111–6. PMID 2291748. 
  27. ^ People with diabetes should say 'yes' to garlic by Patricia Andersen-Parrado, Better Nutrition, Sept 1996
  28. ^ Garlic - University of Maryland Medical Center
  29. ^ Health effects of garlic American Family Physician by Ellen Tattelman, July 1, 2005
  30. ^ Groppo, F.; Ramacciato, J.; Motta, R.; Ferraresi, P.; Sartoratto, A. (2007) "Antimicrobial activity of garlic against oral streptococci." Int. J. Dent. Hyg., 5:109–115.
  31. ^ Fareed G, Scolaro M, Jordan W, Sanders N, Chesson C, Slattery M, Long D, Castro C. The use of a high-dose garlic preparation for the treatment of Cryptosporidium parvum diarrhea. NLM Gateway. Retrieved December 7, 2007.
  32. ^ John S. James. Treatment Leads on Cryptosporisiosis: Preliminary Report on Opportunistic Infection, AIDS TREATMENT NEWS No. 049 - January 29, 1988. Retrieved December 7, 2007.
  33. ^ Oi Y, Imafuku M, Shishido C, Kominato Y, Nishimura S, Iwai K. (2001). "Garlic supplementation increases testicular testosterone and decreases plasma corticosterone in rats fed a high protein diet.". Journal of Nutrition 131 (8): 2150–6. PMID 11481410. 
  34. ^ Kodera Y., Matuura H., Yoshida S., Sumida T., Itakura Y., Fuwa T., Nishino H. (1989-01-30). "Allixin, a stress compound from garlic.". http://joi.jlc.jst.go.jp/JST.JLC/AID/6d45e46d45c048c9062c390a58734a7228bf?from=J-STAGE&type=list&lang=en. Retrieved on 2009-01-30. 
  35. ^ Yamasaki T., Teel R. W., Lau B. H. (1991-08-01). "Effect of allixin, a phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1 = 2009-01-30". http://joi.jlc.jst.go.jp/JST.JLC/AID/6d45e46d45c048c9062c390a58734a7c72bf?from=J-STAGE&type=list&lang=en. 
  36. ^ Yamasaki T., Teel R. W., Lau B. H. (1991-08-01). "Effect of allixin, a phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1 = 2009-01-30". http://joi.jlc.jst.go.jp/JST.JLC/AID/6d45e46d45c048c9062c390a58734a7c72bf?from=J-STAGE&type=list&lang=en. 
  37. ^ Yamasaki T., Teel R. W., Lau B. H. (1991-08-01). "Effect of allixin, a phytoalexin produced by garlic, on mutagenesis, DNA-binding and metabolism of aflatoxin B1 = 2009-01-30". http://joi.jlc.jst.go.jp/JST.JLC/AID/6d45e46d45c048c9062c390a58734a7c72bf?from=J-STAGE&type=list&lang=en. 
  38. ^ McGee p. 310–311
  39. ^ Macpherson et al. section "Conclusion"
  40. ^ Macpherson et al.
  41. ^ Mosquito Repellents
  42. ^ Pickering, David (2003). Cassell's Dictionary of Superstitions. Sterling Publishing. ISBN 0-304-36561-0.  p. 211
  43. ^ a b McNally, Raymond T (1994). In Search of Dracula. Houghton Mifflin. ISBN 0-395-65783-0.  p. 120.
  44. ^ McNally p. 122; Pickering p. 211.
  45. ^ University of Maryland Garlic
  46. ^ Neurodegenerative diseases
  47. ^ Bukhari, Volume 7, Book 65
  48. ^ a b c d Hogg, Jennifer (2002-12-13). "Garlic Supplements" (PDF). Complementary Medicines Summary. UK Medicines Information, National Health Service. http://www.ukmi.nhs.uk/Med_info/documents/GarlicSuppsCMSFinal2.pdf. Retrieved on 2007-07-07. 
  49. ^ Garlic - Allium sativum [NCCAM Herbs at a Glance]
  50. ^ CSU SafeFood Newsletter, Summer 2005 - Vol 9 No. 4 - Botulinum Toxin: Friend or Foe
  51. ^ Health Canada - Garlic-in-Oil
  52. ^ a b MedlinePlus Herbs and Supplements: Garlic (Allium sativum L.)
  53. ^ a b Mayo Clinic, garlic advisory
  54. ^ Histopathological effects of garlic on liver and l...[Toxicol Lett. 1996] - PubMed Result
  55. ^ Abstract
  56. ^ Garty, B.-Z. (1993) Garlic burns. Pediatrics, 91: 658–659.
  57. ^ What you should know about household hazards to pets brochure by the American Veterinary Medical Association

[edit] Bibliography

  • McGee, Harold (2004). On Food and Cooking (Revised Edition). Scribner. ISBN 0-684-80001-2.  pp 310–313: The Onion Family: Onions, Garlic, Leeks.
  • Salunkhe, D.K.; Kadam, S.S. (1998). Handbook of Vegetable Science and Technology. Marcel Dekker. ISBN 0-8247-0105-4. 
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