Lateralization of brain function

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A longitudinal fissure separates the human brain into two distinct cerebral hemispheres, connected by the corpus callosum. The sides resemble each other and each hemisphere's structure is generally mirrored by the other side. Yet despite the strong similarities, the functions of each cortical hemisphere are different.

Popular psychology tends to make broad and sometimes pseudoscientific generalizations about certain functions (e.g. logic, creativity) being lateral, that is, located in either the right or the left side of the brain. Researchers often criticize popular psychology for this, because the popular lateralizations often are distributed across both hemispheres, [1] although mental processing is divided between them.[citation needed]

Many differences between the hemispheres have been observed, from the gross anatomical level to differences in dendritic structure or neurotransmitter distribution. For example, the lateral sulcus generally is longer in the left hemisphere than in the right hemisphere. However, experimental evidence provides little, if any, consistent support for correlating such structural differences with functional differences. (citation: see, for example Toga & Thompson (2003). Mapping brain asymmetry. Nature Reviews Neuroscience (4). 37-48; The extent of specialized brain function by area remains under investigation. If a specific region of the brain is either injured or destroyed, its functions can sometimes be assumed by a neighboring region, even in the opposite hemisphere, depending upon the area damaged and the patient's age. Injury may also interfere with a pathway from one area to another. In this case, alternative (indirect) connections may exist which can be used to transmit the information to the target area. Such transmission may not be as efficient as the original pathway.

While functions are lateralized, the lateralizations are functional trends, which differ across individuals and specific function. Short of having undergone a hemispherectomy (removal of a cerebral hemisphere), no one is a "left-brain only" or "right-brain only" person.

Brain function lateralization is evident in the phenomena of right- or left-handedness and of right or left ear preference, but a person's preferred hand is not a clear indication of the location of brain function. Although 95% of right-handed people have left-hemisphere dominance for language, only 18.8% of left-handed people have right-hemisphere dominance for language function. Additionally, 19.8% of the left-handed have bilateral language functions.[2] Even within various language functions (e.g., semantics, syntax, prosody), degree (and even hemisphere) of dominance may differ.


[edit] Which side?

Linear reasoning[3] and language functions such as grammar and vocabulary[4] often are lateralized to the left hemisphere of the brain. Dyscalculia is a neurological syndrome associated with damage to the left temporo-parietal junction.[5] This syndrome is associated with poor numeric manipulation, poor mental arithmetic skill, and the inability to either understand or apply mathematical concepts.[6]

In contrast, prosodic language functions, such as intonation and accentuation, often are lateralized to the right hemisphere of the brain.[7][8] Functions such as the processing of visual and audiological stimuli, spatial manipulation, facial perception, and artistic ability seem to be functions of the right hemisphere.

Other integrative functions, including arithmetic,[9][10] binaural sound localization, and emotions, seem more bilaterally controlled.

Left hemisphere functions Right hemisphere functions
analytical[11] holistic[3][11]
verbal[3][11][12] prosodic[12]
logical[3][11] intuitive[3][11][13]
numerical computation (exact calculation, numerical comparison, estimation)
left hemisphere only: direct fact retrieval[9][10]
numerical computation (approximate calculation, numerical comparison, estimation)[9][10]
language: grammar/vocabulary, literal[14] language: intonation/accentuation, prosody, pragmatic, contextual[14]

[edit] History

[edit] Speech and language

[edit] Broca

One of the first indications of brain function lateralization resulted from the research of French physician Pierre Paul Broca, in 1861. His research involved the male patient nicknamed "Tan", who suffered a speech deficit (aphasia); "tan" was one of the few words he could articulate, hence his nickname. In Tan's autopsy, Broca determined he had a syphilitic lesion in the left cerebral hemisphere. This left frontal lobe brain area (Broca's Area) is an important speech production region. The motor aspects of speech production deficits caused by damage to Broca’s Area are known as Broca's aphasia. In clinical assessment of this aphasia, it is noted that the patient cannot clearly articulate the language being employed.

[edit] Wernicke

German physician Karl Wernicke continued in the vein of Broca's research by studying language deficits unlike Broca aphasias. Wernicke noted that not every deficit was in speech production; some were linguistic. He found that damage to the left posterior, superior temporal gyrus (Wernicke's area) caused language comprehension deficits rather than speech production deficits, a syndrome known as Wernicke's aphasia.

[edit] Advance in imaging technique

These seminal works on hemispheric specialization were done on patients and/or postmortem brains, raising questions about the potential impact of pathology on the research findings. New methods permit the in vivo comparison of the hemispheres in healthy subjects. Particularly, magnetic resonance imaging (MRI) and positron emission tomography (PET) are important because of their high spatial resolution and ability to image subcortical brain structures.

[edit] Handedness and language

Broca's Area and Wernicke’s Area are linked by a white matter fiber tract, the arcuate fasciculus. This axonal tract allows the neurons in the two areas to work together in creating vocal language. In more than 95% of right-handed men, and more than 90% of right-handed women, language and speech are subserved by the brain's left hemisphere. In left-handed people, the incidence of left-hemisphere language dominance has been reported as 73% [15] and 61%[2].

There are ways of determining hemispheric dominance in a person. The Wada Test introduces an anesthetic to one hemisphere of the brain via one of the two carotid arteries. Once the hemisphere is anesthetized, a neuropsychological examination is effected to determine dominance for language production, language comprehension, verbal memory, and visual memory functions. Less invasive (sometimes costlier) techniques, such as functional magnetic resonance imaging and Transcranial magnetic stimulation, also are used to determine hemispheric dominance; usage remains controversial for being experimental.

Sensory and motor homunculi at the London Natural History Museum

[edit] Movement and sensation

In the 1940s, Canadian neurosurgeon Wilder Penfield and his neurologist colleague Herbert Jasper developed a technique of brain mapping to help reduce side effects caused by surgery to treat epilepsy. They stimulated motor and somatosensory cortices of the brain with small electrical currents to activate discrete brain regions. They found that stimulation of one hemisphere's motor cortex produces muscle contraction on the opposite side of the body. Furthermore, the functional map of the motor and sensory cortices is fairly consistent from person to person; Penfield and Jasper's famous pictures of the motor and sensory homunculi were the result.

[edit] Split-brain patients

Research by Michael Gazzaniga and Roger Wolcott Sperry in the 1960s on split-brain patients led to an even greater understanding of functional laterality. Split-brain patients are patients who have undergone corpus callosotomy (usually as a treatment for severe epilepsy), a severing of a large part of the corpus callosum. The corpus callosum connects the two hemispheres of the brain and allows them to communicate. When these connections are cut, the two halves of the brain have a reduced capacity to communicate with each other. This led to many interesting behavioral phenomena that allowed Gazzaniga and Sperry to study the contributions of each hemisphere to various cognitive and perceptual processes. One of their main findings was that the right hemisphere was capable of rudimentary language processing, but often has no lexical or grammatical abilities[16]. Eran Zaidel, however, also studied such patients and found some evidence for the right hemisphere having at least some syntactic ability.

[edit] Pseudoscientific exaggeration of the research

Hines (1987) states that the research on brain lateralization is valid as a research program, though commercial promoters have applied it to promote subjects and products far out of the implications of the research. For example, the implications of the research have no bearing on psychological interventions such as EMDR and neurolinguistic programming (Drenth 2003:53), brain training equipment, or management training. One explanation for why research on lateralization is so prone to exaggeration and false application is that the left-right brain dichotomy is an easy-to-understand notion, which can be oversimplified and misused for promotion in the guise of science.[17] The research on lateralization of brain functioning is ongoing, and its implications are always tightly delineated, whereas the pseudoscientific applications are exaggerated, and applied to an extremely wide range of situations.

[edit] See also

[edit] References

  1. ^ Western et al. 2006 "Psychology: Austraian and New Zealand edition" John Wiley p.107
  2. ^ a b Taylor, Insep and Taylor, M. Martin (1990) "Psycholinguistics: Learning and using Language". page 362
  3. ^ a b c d e Left/Right Processing.
  4. ^ Dr. C. George Boeree. Speech and the Brain.
  5. ^ Levy LM, Reis IL, Grafman J. Metabolic abnormalities detected by 1H-MRS in dyscalculia and dysgraphia. Neurology. 1999 Aug 11;53(3):639-41. PMID 10449137
  6. ^ Dyscalculia Symptoms
  7. ^ Ross ED, Monnot M (January 2008). "Neurology of affective prosody and its functional-anatomic organization in right hemisphere". Brain Lang. 104 (1): 51-74. PMID 17537499. 
  8. ^ George MS, Parekh PI, Rosinsky N, Ketter TA, Kimbrell TA, Heilman KM, Herscovitch P, Post RM (July 1996). "Understanding Emotional Prosody Activates Right Hemisphere Regions". Arch Neurol. 53 (7): 665-670. PMID 8929174. 
  9. ^ a b c Dehaene S, Spelke E, Pinel P, Stanescu R, Tsivkin S. Sources of mathematical thinking: behavioral and brain-imaging evidence. Science. 1999 May 7;284(5416):970-4. PMID 10320379.
  10. ^ a b c Stanislas Dehaene, Manuela Piazza, Philippe Pinel, and Laurent Cohen. Three parietal circuits for number processing. Cognitive Neuropsychology, 20:487-506
  11. ^ a b c d e Right-Brain Hemisphere
  12. ^ a b Handedness and Brain Lateralization.
  13. ^ Converting Words into Pictures--Reading Comprehension Guide--Academic Support
  14. ^ a b Taylor, Insep, and Taylor, M. Martin (1990) "Psycholinguistics: Learning and using Language". p. 367
  15. ^ Knecht S, Dräger B, Deppe M, Bobe L, Lohmann H, Flöel A, Ringelstein EB, Henningsen H. Handedness and hemispheric language dominance in healthy humans. Brain. 2000;123(12):2512-2518.
  16. ^ Kandel E, Schwartz J, Jessel T. Principles of Neural Science. 4th ed. p1182. New York: McGraw-Hill; 2000. ISBN 0-8385-7701-6
  17. ^ Sala, (1999). Mind Myths: Exploring Popular Assumptions about the Mind and Brain. New York; Wiley

[edit] Sources

[edit] Further reading

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