Prednisone
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Prednisone
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| Systematic (IUPAC) name | |
| (8S,9S,10R,13S,14S,17R)-
17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,10,12,13,14,15,16,17- decahydro-3H-cyclopenta[a]phenanthrene-3,11(6H)-dione |
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| Identifiers | |
| CAS number | |
| ATC code | A07 H02 |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| Chemical data | |
| Formula | C21H26O5 |
| Mol. mass | 358.428 g/mol |
| SMILES | & |
| Pharmacokinetic data | |
| Bioavailability | 70% |
| Metabolism | prednisolone (liver) |
| Half life | 1 hour |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
C |
| Legal status |
Prescription only |
| Routes | Oral, Nasal, Rectal, Injection, IV |
Prednisone is a synthetic corticosteroid drug that is usually taken orally but can be delivered by intramuscular injection and can be used for a number of different conditions. It has a mainly glucocorticoid effect. Prednisone is a prodrug that is converted by the liver into prednisolone, which is the active drug and also a steroid.
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[edit] Uses
Prednisone is particularly effective as an immunosuppressant, and affects virtually all of the immune system. It can, therefore, be used in autoimmune diseases, inflammatory diseases (such as severe asthma, severe allergies, Angioedema episodes, severe poison ivy dermatitis, systemic lupus erythematosus, ulcerative colitis, rheumatoid arthritis, Bell's Palsy, Crohn's disease, pemphigus and sarcoidosis), uveitis, various kidney diseases including nephrotic syndrome, mononucleosis [Epstein Barr virus], and to prevent and treat rejection in organ transplantation. Prednisone has also been used in the treatment of migraine headaches and cluster headaches and for severe Aphthous ulcer ("Cankersore") outbreaks.
Prednisone is used as an antitumor drug. Prednisone is very important in the treatment of acute lymphoblastic leukemia, Non-Hodgkin's lymphomas, Hodgkin's Lymphoma, multiple myeloma, and other tumors in combination with other anticancer drugs.
Furthermore, the pharmaceutical industry uses prednisone tablets for the calibration of dissolution testing equipment according to the United States Pharmacopeia (USP).
Intravenous application may be employed for cerebral inflammation, as in the periodic attacks caused by multiple sclerosis.
Prednisone is also used for the treatment of the Jarisch-Herxheimer Reaction which is common during the treatment of syphilis, and to delay the onset of symptoms of Duchenne muscular dystrophy. The mechanism for the delay of symptoms is unknown.
[edit] History
The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation, by Arthur Nobile and coworkers. [1] They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. The same process was used to prepare prednisolone from hydrocortisone. [2] Their discovery was protected by US Patents 2,837,464 (1958); 2,897,216 (1959); and 3,134,718 (1964). The enhanced adrenocorticoid activity of these compounds over cortisone and hydrocortisone was demonstrated in mice. [3] Prednisone and prednisolone were introduced by Schering in the mid-1960s under the brand names Meticorten and Meticortelone respectively. These prescription medicines are now available from a number of manufacturers of generic drugs.
[edit] Dependency
Adrenal suppression will occur if prednisone is taken for longer than 7 days. This will cause the body to lose the ability to synthesize natural corticosteroids, resulting in dependence on prednisone. For this reason, prednisone should not be abruptly stopped if taken for more than seven days, and instead, the dosage should be gradually reduced. This weaning process may be over a few days if the course of prednisone was short, but may take weeks or months if the patient had been on long-term treatment. Abrupt withdrawal may lead to an Addisonian crisis. For those on chronic therapy, alternate-day dosing may preserve adrenal function, thereby reducing side-effects.[4]
Glucocorticoids act to feedback inhibit both the hypothalamus (decreasing Corticotropin-releasing hormone [CRH]) and corticotrophs in the anterior pituitary gland (decreasing the amount of Adrenocorticotropic hormone [ACTH]). For this reason exogenous glucocorticoid analogues down-regulate the body's ability to naturally produce glucocorticoids. This mechanism leads to dependence in a short time and can be very dangerous if medications are withdrawn too quickly. The body must have time to begin synthesis of CRH and ACTH and for the adrenal glands to begin functioning normally again.
[edit] Side-effects
Short-term side-effects, as with all glucocorticoids, include high blood glucose levels, especially in patients that already have diabetes mellitus or are on other medications that increase blood glucose (such as tacrolimus), and mineralocorticoid effects such as fluid retention (it is worth noting, however, that the mineralocorticoid effects of prednisone are very minor; this is why it is not used in the management of adrenal insufficiency unless a more potent mineralocorticoid is administered concomitantly). Additional short-term side-effects include insomnia, euphoria, and, rarely, mania. Long-term side-effects include Cushing's syndrome, truncal weight gain, osteoporosis, glaucoma, type II diabetes mellitus, and depression upon withdrawal.
[edit] Major
- increased blood sugar for diabetics
- weight gain
- facial swelling
- depression, mania, or other psychiatric symptoms
- unusual fatigue or weakness
- mental confusion / indecisiveness
- blurred vision
- abdominal pain
- peptic ulcer
- infections
- painful hips or shoulders
- Steroid-induced osteoporosis
- Long term migraines
- insomnia
- severe joint pain
- cataracts
- anxiety
- black stool
- stomach pain or bloating
- severe swelling
- mouth sores or dry mouth
- Avascular Necrosis
[edit] Minor
- hyperactivity
- frequent urination
- diarrhea
- removes intestinal flora
- leg pain
[edit] References
- ^ Merck Index, 14th Edition, p.1327. Published by Merck & Co. Inc.
- ^ A.Nobile "et al." Journal of the American Chemical Society Vol 77, p.4184 (1955).
- ^ H.L. Herzog et al. Science, Vol. 121, p 176 (1955).
- ^ "Therapeutic and Adverse Effects of Glucocorticoids". U.S. Pharmacist. http://www.uspharmacist.com/NewLook/CE/glucocort/lesson.htm.
National Inventors Hall of Fame induction of Arthur Nobile [1]
[edit] External links
- Kelly, Janis (July 2000). "Prednisone-related growth impairment persists in children with CF". Respiratory Reviews 5 (7). http://www.respiratoryreviews.com/jul00/rr_jul00_prednisone.html.
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