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Linus Pauling
Linus Pauling in 1954
Born	28 February 1901(1901-02-28) Portland, Oregon, USA
Died	19 August 1994 (aged 93) Big Sur, California, USA
Residence	United States
Nationality	United States
Fields	Quantum chemistry Biochemistry
Institutions	Caltech, UCSD, Stanford
Alma mater	Oregon Agricultural College Caltech
Doctoral advisor	Roscoe G. Dickinson
Other academic advisors	Arnold Sommerfeld Erwin Schrödinger Niels Bohr
Doctoral students	Jerry Donohue Martin Karplus Matthew Meselson Edgar Bright Wilson William Lipscomb
Known for	Elucidating the nature of chemical bonds and the structures of molecules Advocating nuclear disarmament
Notable awards	Nobel Prize in Chemistry (1954) Nobel Peace Prize (1962)
Religious stance	Raised Lutheran, Unitarian Universalist, Atheist as an adult
Notes The first person to win unshared Nobel Prizes in two different fields

Linus Carl Pauling (February 28, 1901 – August 19, 1994) was an American scientist, peace activist, author and educator. He was one of the most influential chemists in history and ranks among the most important scientists in any field of the 20th century. Pauling was among the first scientists to work in the fields of quantum chemistry, molecular biology and orthomolecular medicine. He is one of only 4 individuals to have won multiple Nobel Prizes, the only one to win two in unrelated fields,^[1] and the only person to have been awarded each of his prizes without sharing it with another recipient.^[2]

Pauling was born and raised in Oregon. He attended Oregon Agricultural College (now Oregon State University) and graduated in 1922 with a degree in chemical engineering. Pauling then went to the California Institute of Technology (Caltech), where he received his Ph. D in physical chemistry and mathematical physics in 1925. Two years later, he accepted a position at Caltech as an assistant professor in theoretical chemistry. In 1932, Pauling published a landmark paper, detailing his theory of orbital hybridization and analyzed the tetravalency of carbon. That year, he also established the concept of electronegativity and developed a scale that would help predict the nature of chemical bonding. Pauling continued this work, but also began publishing papers on the structure of the atomic nucleus. In 1954, Pauling was awarded the Nobel Prize in Chemistry. As a biochemist, Pauling conducted research with X-ray crystallography and modeling in crystal and protein structures. This type of approach was used by Rosalind Franklin, James Watson and Francis Crick in the U.K to discover the double helix structure of the DNA molecule.

During the Second World War, Pauling worked on military research and development. However, when the war ended he became particularly concerned about the further development and possible use of atomic weapons and with the destruction inflicted on the world by war in general. Ava Helen Pauling, Linus's wife, was a pacifist and in time he came to share her views.^[3] Pauling soon began to express his concerns with the effects of nuclear fallout and in 1962, was awarded the Nobel Peace Prize for his campaign against above ground nuclear testing. His beliefs were not without controversy at the time and he was criticized by some for his actions.

Pauling was also successful as an author and educator. His first book, The Nature of the Chemical Bond (1939), is considered influential even to this day, as is his introductory textbook, General Chemistry (1949). Later in life, he became an advocate for greatly increased consumption of vitamin C and other nutrients. He generalized his ideas to define orthomolecular medicine, which is still regarded as unorthodox by conventional medicine. He popularized his concepts, analyses, research and insights in several successful but controversial books, such as How to Live Longer and Feel Better in 1986.

Contents 1 Biography 1.1 Early years 1.1.1 Higher education 1.1.2 Personal life 1.2 Career 1.2.1 Activism 1.2.2 Biological molecules 1.2.3 Molecular genetics 1.2.4 Molecular medicine and medical research 1.2.5 Nature of the chemical bond 1.2.6 Structure of the atomic nucleus 2 Legacy 3 Honors and awards 4 Publications 5 See also 6 Notes 7 References 8 Further reading 9 External links

[edit] Biography

[edit] Early years

Pauling was born in Portland, Oregon as the first born child to Herman Henry William Pauling (1876–1910) and Lucy Isabelle "Belle" Darling (1881–1926).^[4] He was named "Linus Carl", in honor of Lucy's father, Linus, and Herman's father, Carl.^[5] Herman and Lucy—then 23 and 18 years old, respectively—had met at a dinner party in Condon. Six months later, the two were married.^[6]

Herman Pauling descended from South-German farmers, who had immigrated to a German settlement in Concordia, Missouri. Carl Pauling moved his family to California before settling in Oswego. There, he worked as an ironmonger at a foundry.^[7] After completing grammar school, Herman Pauling served as an apprentice to a druggist. Upon completion of his services, he became a wholesale drug salesman.^[8]

Pauling's mother, Lucy, of Irish descent, was the daughter of Linus Wilson Darling, who had served as a teacher, farmer, surveyor, postmaster and lawyer at different points of his life. Linus Darling was orphaned at age 11 and apprenticed under a baker before becoming a schoolteacher. He fell in love with a young woman named Alice from Turner, Oregon, whom he eventually married.^[9] On July 17, 1888, Alice gave birth to the couple's fifth child, but he was stillborn. Less than a month later, she died, leaving Darling to take care of their four young daughters.^[10]

Linus Pauling spent his first year living in a one-room apartment with his parents in Portland. In 1902, after his sister Pauline was born, Pauling's parents decided to move out of the city.^[11] They were crowded in their apartment, but couldn't afford more spacious living quarters in Portland. Lucy stayed with her husband's parents in Oswego, while Herman searched for new housing. Herman brought the family to Salem, where he took up a job as a traveling salesman for the Skidmore Drug Company. Within a year of Lucile's birth in 1904, Herman Pauling moved his family to Oswego, where he opened his own drugstore.^[11] The business climate in Oswego was poor, so he moved his family to Condon in 1905.^[12]

In 1909, Pauling's grandfather, Linus, divorced his second wife and married a young schoolteacher, almost the same age as his daughter Lucy. A few months later, he died of a heart attack, brought on by complications from nephritis.^[13] Meanwhile, Herman Pauling was suffering from poor health and had regular sharp pains in his abdomen. Lucy's sister, Abbie, saw that Herman was dying and immediately called the family physician. The doctor gave Herman a sedative to reduce the pain, but it only offered temporary relief.^[14] His health worsened in the coming months and finally died of a perforated ulcer on June 11, 1910, leaving Lucy to care for Linus, Lucile and Pauline.^[15]

Linus was a voracious reader as a child, and at one point his father wrote a letter to The Oregonian inviting suggestions of additional books to occupy his time.^[16] Pauling first planned to become a chemist after being amazed by experiments conducted with a small chemistry lab kit by his friend, Lloyd A. Jeffress.^[17] In high school, Pauling continued to conduct chemistry experiments, borrowing much of the equipment and material from an abandoned steel plant. With an older friend, Lloyd Simon, Pauling set up Palmon Laboratories. Operating from Simon's basement, the two young adults approached local dairies to offer their services in performing butterfat samplings at cheap prices. Dairymen were wary of trusting two young boys with the task, and as such, the business ended as a failure.^[18]

By the fall of 1916, Pauling was a 15-year-old high school senior and had enough credits to enter Oregon Agricultural College (OAC, now known as Oregon State University) in Corvallis.^[19] However, he did not have credit for two required American history courses that would satisfy his requirement to earn a high school diploma. He asked the school principal if he could take these courses concurrently during the spring semester. The principal denied his request, and Pauling decided to leave the school in June without a diploma.^[20] His high school, Washington High School in Portland, awarded him the diploma 45 years later, after he had won two Nobel Prizes.^[21][22] During the summer, Pauling worked part-time at a grocery store, earning eight dollars a week. His mother set him up with an interview with a Mr. Schwietzerhoff, the owner of a number of manufacturing plants in Portland. Pauling was hired as an apprentice machinist with a salary of 40 dollars a month. Pauling excelled at his job, and saw his salary increase to 50 dollars a month after being on the job for only a month.^[23] In his spare time, he set up a photography lab with two friends and found business from a local photography company. He hoped that the business would earn him enough money to pay for his future college expenses.^[24] Pauling received a letter of admission from OAC in September 1917 and immediately gave notice to his boss and told his mother of his plans.^[25]

[edit] Higher education

In October 1917, Pauling entered Oregon Agricultural College and lived in a boarding house on campus with his cousin Mervyn and another man, using the $200 he had saved from odd jobs to finance his education. In his first semester, Pauling registered for two courses in chemistry, two in mathematics, mechanical drawing, introduction to mining and use of explosives, modern English prose, gymnastics and military drill.^[26] Pauling fell in love with a freshman girl named Irene early in the school year. By the end of October, he had used up $150 of his savings on her, taking her to shows and games. He soon got a job at the girls' dormitory, working 100 hours a month chopping wood for stoves, cutting up beef and mopping up the kitchen. Despite the 25 cent per hour salary, Pauling was still having trouble managing his finances. He began eating one hot meal a day at a restaurant off campus to minimize his expenses.^[26] Pauling was active in campus life and founded the school's chapter of the Delta Upsilon fraternity.^[27] After his second year, he planned to take a job in Portland to help support his mother, but the college offered him a position teaching quantitative analysis, a course he had just finished taking himself. He worked forty hours a week in the laboratory and classroom and earned $100 a month.^[28] This allowed him to continue his studies at the college.

In his last two years at school, Pauling became aware of the work of Gilbert N. Lewis and Irving Langmuir on the electronic structure of atoms and their bonding to form molecules.^[28] He decided to focus his research on how the physical and chemical properties of substances are related to the structure of the atoms of which they are composed, becoming one of the founders of the new science of quantum chemistry. Pauling began to neglect his studies in humanities and social sciences. He had also exhausted the course offerings in the physics and mathematics departments. Professor Samuel Graf selected Pauling to be his teaching assistant in a high-level mathematics course.^[29] During the winter of his senior year, Pauling was approached by the college to teach a chemistry course for home economics majors. It was in one of these classes that Pauling met his future wife, Ava Helen Miller.^[30]

In 1922, Pauling graduated from OAC with a degree in chemical engineering and went on to graduate school at the California Institute of Technology (Caltech) in Pasadena, California, under the guidance of Roscoe G. Dickinson. His graduate research involved the use of X-ray diffraction to determine the structure of crystals. He published seven papers on the crystal structure of minerals while he was at Caltech. He received his Ph. D. in physical chemistry and mathematical physics, summa cum laude, in 1925.

[edit] Personal life

During his senior year of college, Pauling taught a class called "Chemistry for Home Economic Majors".^[31] In one of those classes, he met Ava Helen Miller from Beavercreek, whom he married on June 17, 1923. They had four children: Linus Carl Jr. (b. 1925); Peter Jeffress (1931-2003, a crystallographer and lecturer in chemistry); Edward Crellin (1937-1997, professor of biology at San Francisco State University and the University of California, Riverside), and Linda Helen, (b. 1932).

Pauling was raised as member of the Lutheran Church, but later joined the Unitarian Universalist Church and declared publicly his atheist belief two years before his death.^[32]

[edit] Career

Pauling had first been exposed to the concepts of quantum theory and quantum mechanics while he was studying at Oregon State University. He later traveled to Europe on a Guggenheim Fellowship to study under German physicist Arnold Sommerfeld in Munich, Danish physicist Niels Bohr in Copenhagen, and Austrian physicist Erwin Schrödinger in Zürich. All three were experts working in the new field of quantum mechanics and other branches of physics. Pauling became interested in seeing how quantum mechanics might be applied in his chosen field of interest, the electronic structure of atoms and molecules. In Europe, Pauling was also exposed to one of the first quantum mechanical analyses of bonding in the hydrogen molecule, done by Walter Heitler and Fritz London. Pauling devoted the two years of his European trip to this work and decided to make it the focus of his future research. He became one of the first scientists in the field of quantum chemistry and a pioneer in the application of quantum theory to the structure of molecules. He also joined Alpha Chi Sigma, the professional chemistry fraternity.

In 1927, Pauling took a new position as an assistant professor at Caltech in theoretical chemistry. He launched his faculty career with a very productive five years, continuing with his X-ray crystal studies and also performing quantum mechanical calculations on atoms and molecules. He published approximately fifty papers in those five years, and created five rules now known as Pauling's Rules. By 1929, he was promoted to associate professor, and by 1930, to full professor. In 1931, the American Chemical Society awarded Pauling the Langmuir Prize for the most significant work in pure science by a person 30 years of age or younger.^[33] The following year, Pauling published what he regarded as his most important paper, in which he first laid out the concept of hybridization of atomic orbitals and analyzed the tetravalency of the carbon atom.^[34]

At Caltech, Pauling struck up a close friendship with theoretical physicist Robert Oppenheimer, who was spending part of his research and teaching schedule away from U.C. Berkeley at Caltech every year. The two men planned to mount a joint attack on the nature of the chemical bond: apparently Oppenheimer would supply the mathematics and Pauling would interpret the results. However, their relationship soured when Pauling began to suspect that Oppenheimer was becoming too close to Pauling's wife, Ava Helen. Once, when Pauling was at work, Oppenheimer had come to their place and blurted out an invitation to Ava Helen to join him on a tryst in Mexico. Although she flatly refused, she reported the incident to Pauling. Disquieted by this strange chemistry, and her apparent nonchalance about the incident, he immediately cut off his relationship with Oppenheimer.

In the summer of 1930, Pauling made another European trip, during which he learned about the use of electrons in diffraction studies similar to the ones he had performed with X-rays. After returning, he built an electron diffraction instrument at Caltech with a student of his, L. O. Brockway, and used it to study the molecular structure of a large number of chemical substances.

Pauling introduced the concept of electronegativity in 1932. Using the various properties of molecules, such as the energy required to break bonds and the dipole moments of molecules, he established a scale and an associated numerical value for most of the elements—the Pauling Electronegativity Scale—which is useful in predicting the nature of bonds between atoms in molecules.

[edit] Activism

Pauling had been practically apolitical until World War II, but the aftermath of the war and his wife's pacifism changed his life profoundly, and he became a peace activist. During the beginning of the Manhattan Project, Robert Oppenheimer invited him to be in charge of the Chemistry division of the project, but he declined, not wanting to uproot his family. He did work on other projects that had military applications such as explosives, rocket propellants, an oxygen meter for submarines and patented an armor piercing shell and was awarded a Presidential Medal of Merit.^[3][35] In 1946, he joined the Emergency Committee of Atomic Scientists, chaired by Albert Einstein.^[36] Its mission was to warn the public of the dangers associated with the development of nuclear weapons. His political activism prompted the U.S. State Department to deny him a passport in 1952, when he was invited to speak at a scientific conference in London.^[37][38] His passport was restored in 1954, shortly before the ceremony in Stockholm where he received his first Nobel Prize. Joining Einstein, Bertrand Russell and eight other leading scientists and intellectuals, he signed the Russell-Einstein Manifesto in 1955.^[39]

In 1958, Pauling began a petition drive in cooperation with biologist Barry Commoner, who had studied radioactive strontium-90 in the baby teeth of children across North America and concluded that above-ground nuclear testing posed public health risks in the form of radioactive fallout.^[40][41] He also participated in a public debate with the atomic physicist Edward Teller about the actual probability of fallout causing mutations.^[42] In 1958, Pauling and his wife presented the United Nations with a petition signed by more than 11,000 scientists calling for an end to nuclear-weapon testing. Public pressure subsequently led to a moratorium on above-ground nuclear weapons testing, followed by the Partial Test Ban Treaty, signed in 1963 by John F. Kennedy and Nikita Khrushchev. On the day that the treaty went into force, the Nobel Prize Committee awarded Pauling the Nobel Peace Prize, describing him as "Linus Carl Pauling, who ever since 1946 has campaigned ceaselessly, not only against nuclear weapons tests, not only against the spread of these armaments, not only against their very use, but against all warfare as a means of solving international conflicts."^[43] The Caltech Chemistry Department, wary of his political views, did not even formally congratulate him. However, the Biology Department did throw him a small party, showing they were more appreciative and sympathetic toward his work on radiation mutation. At Caltech he founded Sigma Xi's (The Scientific Research Society) chapter at the school, as he had previously been a member of that organisation. He continued his peace activism in the following years co-founding the International League of Humanists in 1974. He was president of the scientific advisory board of the World Union for Protection of Life and also one of the signers of the Dubrovnik-Philadelphia Statement.

Many of Pauling's critics, including scientists who appreciated the contributions that he had made in chemistry, disagreed with his political positions and saw him as a naive spokesman for Soviet communism. He was ordered to appear before the Senate Internal Security Subcommittee, which termed him "the number one scientific name in virtually every major activity of the Communist peace offensive in this country." An extraordinary headline in Life magazine characterized his 1962 Nobel Prize as "A Weird Insult from Norway". Pauling was awarded the International Lenin Peace Prize by the USSR in 1970.

[edit] Biological molecules

Double Helix Discovery
William Astbury
Oswald Avery
Francis Crick
Erwin Chargaff
Max Delbrück
Jerry Donohue
Rosalind Franklin
Raymond Gosling
Phoebus Levene
Linus Pauling
Sir John Randall
Erwin Schrödinger
Alex Stokes
James Watson
Maurice Wilkins
Herbert Wilson

In the mid-1930s, Pauling decided to strike out into new areas of interest. Early in his career, he was uninterested in studying molecules of biological importance. But as Caltech was developing a new strength in biology, and Pauling interacted with such great biologists as Thomas Hunt Morgan, Theodosius Dobzhanski, Calvin Bridges, and Alfred Sturtevant, he changed his mind and switched to the study of biomolecules. His first work in this area involved the structure of hemoglobin. He demonstrated that the hemoglobin molecule changes structure when it gains or loses an oxygen atom. As a result of this observation, he decided to conduct a more thorough study of protein structure in general. He returned to his earlier use of X-ray diffraction analysis. But protein structures were far less amenable to this technique than the crystalline minerals of his former work. The best X-ray pictures of proteins in the 1930s had been made by the British crystallographer William Astbury, but when Pauling tried, in 1937, to account for Astbury's observations quantum mechanically, he could not.

It took eleven years for Pauling to explain the problem: his mathematical analysis was correct, but Astbury's pictures were taken in such a way that the protein molecules were tilted from their expected positions. Pauling had formulated a model for the structure of hemoglobin in which atoms were arranged in a helical pattern, and applied this idea to proteins in general.

In 1951, based on the structures of amino acids and peptides and the planarity of the peptide bond, Pauling and colleagues correctly proposed the alpha helix and beta sheet as the primary structural motifs in protein secondary structure. This work exemplified his ability to think unconventionally; central to the structure was the unorthodox assumption that one turn of the helix may well contain a non-integral number of amino acid residues.

Pauling then proposed that deoxyribonucleic acid (DNA) was a triple helix;^[44] however, his model contained several basic mistakes, including a proposal of neutral phosphate groups, an idea that conflicted with the acidity of DNA. Sir Lawrence Bragg had been disappointed that Pauling had won the race to find the alpha helix structure of proteins. Bragg's team had made a fundamental error in making their models of protein by not recognizing the planar nature of the peptide bond. When it was learned at the Cavendish Laboratory that Pauling was working on molecular models of the structure of DNA, Watson and Crick were allowed to make a molecular model of DNA using unpublished data from Maurice Wilkins and Rosalind Franklin at King's College. Early in 1953 James D. Watson and Francis Crick proposed a correct structure for the DNA double helix. One of the impediments facing Pauling in this work was that he did not have access to the high quality X-ray diffraction photographs of DNA taken by Rosalind Franklin, which Watson and Crick had seen. He planned to attend a conference in England, where he might have been shown the photos, but he could not do so because his passport was withheld in 1952 by the State Department, on suspicions that he had Communist sympathies. This was at the start of the McCarthy period in the United States.^[45]

Pauling also studied enzyme reactions and was among the first to point out that enzymes bring about reactions by stabilizing the transition state of the reaction, a view which is central to understanding their mechanism of action. He was also among the first scientists to postulate that the binding of antibodies to antigens would be due to a complementarity between their structures. Along the same lines, with the physicist turned biologist Max Delbruck, he wrote an early paper arguing that DNA replication was likely to be due to complementarity, rather than similarity, as suggested by a few researchers. This was made clear in the model of the structure of DNA that Watson and Crick discovered.

[edit] Molecular genetics

In November 1949, Linus Pauling, Harvey Itano, S. J. Singer and Ibert Wells published "Sickle Cell Anemia, a Molecular Disease"^[46] in the journal Science. It was the first proof of a human disease caused by an abnormal protein, and sickle cell anemia became the first disease understood at the molecular level. Using electrophoresis, they demonstrated that individuals with sickle cell disease had a modified form of hemoglobin in their red blood cells, and that individuals with sickle cell trait had both the normal and abnormal forms of hemoglobin. This was also the first demonstration that Mendelian inheritance determined the specific physical properties of proteins, not simply their presence or absence—the dawn of molecular genetics.

[edit] Molecular medicine and medical research

In 1941, at age 40, Pauling was diagnosed with Bright’s disease, a renal disease. Experts believed then that Bright's disease was untreatable. With the help of Dr. Thomas Addis at Stanford, Pauling was able to control the disease with Addis' then unusual, low protein, salt-free diet. Addis also prescribed vitamins and minerals for all his patients.

In 1951, Pauling gave a lecture entitled, "Molecular Medicine".^[47] In the late 1950s, Pauling worked on the role of enzymes in brain function, believing that mental illness may be partly caused by enzyme dysfunction. It wasn't until he read "Niacin Therapy in Psychiatry" by Abram Hoffer in 1965 that he realized that vitamins might have important biochemical effects unrelated to their prevention of associated deficiency diseases. Pauling published a brief paper, "Orthomolecular psychiatry", in the journal Science in 1968 (PMID 5641253) that gave name and principle to the popular but controversial megavitamin therapy movement of the 1970s. Pauling coined the term "orthomolecular" to refer to the practice of varying the concentration of substances normally present in the body to prevent and treat disease. His ideas formed the basis of orthomolecular medicine, which is not generally practiced by conventional medical professionals and is strongly criticized by some.^[48][49]

Pauling's work on vitamin C in his later years generated much controversy. He was first introduced to the concept of high-dose vitamin C by biochemist Irwin Stone in 1966. After becoming convinced of its worth, Pauling took 3 grams of vitamin C every day to prevent colds (Dunitz 1996:333). Excited by the results, he researched the clinical literature and published Vitamin C and the Common Cold in 1970. He began a long clinical collaboration with the British cancer surgeon Ewan Cameron in 1971 on the use of intravenous and oral vitamin C as cancer therapy for terminal patients.^[50] Cameron and Pauling wrote many technical papers and a popular book, "Cancer and Vitamin C", that discussed their observations. Pauling made vitamin C popular with the public, but the medical establishment regarded his claims that vitamin C could prevent colds and cure cancer as quackery (Dunitz 1996:333), and considered the case closed after two randomized trials conducted by the Mayo Clinic and published in the New England Journal of Medicine failed to replicate^[51] Pauling's study, which found that vitamin C supplementation lengthened survival times significantly.^[52] Pauling denounced the conclusions of these studies and handling of the final study as "fraud and deliberate misrepresentation."^[53][54] Pauling's original study, based on the observational studies of intravenous vitamin C by McCormick and Klenner, used intravenous vitamin C for the first ten days, but the randomized trials did not.^[51] Pauling published critiques of the second Mayo-Moertel cancer trial's flaws over several years as he was able to slowly unearth some of the trial's undisclosed details.^[55] However, the wave of adverse publicity generated by Moertel and the media effectively undercut Pauling's credibility and his vitamin C work for a generation,^[56] the oncological mainstream continued with other avenues of treatment.^[57] Always precariously perched since his molecular biologically inspired crusade to stop atmospheric nuclear testing in the 1950s,^[58] the 1985 Mayo-Moertel confrontation left Pauling isolated from his institutional funding sources, academic support and a bemused public. He later collaborated with the Canadian physician Abram Hoffer on a micronutrient regimen, including high-dose vitamin C, as adjunctive cancer therapy.^[59] Of late the "connection between vitamin C and cancer has become a respectable topic", and it was the subject of a Washington DC NIH conference in 1990 (Dunitz 1996:334).

As of 2007, new evidence of high-dose Vitamin C efficacy was proposed by a Canadian group of researchers based on intravenous vitamin C. Intravenous vitamin C can achieve plasma concentrations up to 70-fold higher than oral vitamin C.^[60]The selective toxicity of vitamin C for cancer cells has been demonstrated in-vitro (i.e., in a cell culture Petri dish), and was reported in 2005.^[61] The combination of case-report data and preclinical information suggest biological plausibility and the possibility of clinical efficacy at the possible expense of critical toxicity at active doses; future clinical testing will ultimately determine the utility and safety of intravenous high-dose Vitamin C treatments for patients with cancer. Researchers released a paper demonstrating in-vivo vitamin C killing of cancer cells in The Proceedings of the National Academy of Sciences in 2007.^[62] These researchers observed longer-than expected survival times in three patients treated with high doses of intravenous Vitamin C.^[63] The researchers are reportedly planning a new Phase I clinical trial.^[64]

With two colleagues, Pauling founded the Institute of Orthomolecular Medicine in Menlo Park, California, in 1973, which was soon renamed the Linus Pauling Institute of Science and Medicine. Pauling directed research on vitamin C, but also continued his theoretical work in chemistry and physics until his death. In his last years, he became especially interested in the possible role of vitamin C in preventing atherosclerosis and published three case reports on the use of lysine and vitamin C to relieve angina pectoris. In 1996, the Linus Pauling Institute moved from Palo Alto, California, to Corvallis, Oregon, to become part of Oregon State University, where it continues to conduct research on micronutrients, phytochemicals (chemicals from plants), and other constituents of the diet in preventing and treating disease. Several of the employees that had previously worked at the Linus Pauling Institute in Palo Alto moved on to form the Genetic Information Research Institute.

[edit] Nature of the chemical bond

In the 1930s Pauling began publishing papers on the nature of the chemical bond, leading to his famous textbook on the subject published in 1939. It is based primarily on his work in this area that he received the Nobel Prize in Chemistry in 1954 "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances". Pauling summarized his work on the chemical bond in The Nature of the Chemical Bond, one of the most influential chemistry books ever published.^[65] In the 30 years after its first edition was published in 1939, the book was cited more than 16,000 times. Even today, many modern scientific papers and articles in important journals cite this work, more than half a century after first publication.

Part of Pauling's work on the nature of the chemical bond led to his introduction of the concept of orbital hybridization.^[66] While it is normal to think of the electrons in an atom as being described by orbitals of types such as s and p, it turns out that in describing the bonding in molecules, it is better to construct functions that partake of some of the properties of each. Thus the one 2s and three 2p orbitals in a carbon atom can be combined to make four equivalent orbitals (called sp³ hybrid orbitals), which would be the appropriate orbitals to describe carbon compounds such as methane, or the 2s orbital may be combined with two of the 2p orbitals to make three equivalent orbitals (called sp² hybrid orbitals), with the remaining 2p orbital unhybridized, which would be the appropriate orbitals to describe certain unsaturated carbon compounds such as ethylene. Other hybridization schemes are also found in other types of molecules.

Another area which he explored was the relationship between ionic bonding, where electrons are transferred between atoms, and covalent bonding where electrons are shared between atoms on an equal basis. Pauling showed that these were merely extremes, between which most actual cases of bonding fall. It was here especially that Pauling's electronegativity concept was particularly useful; the electronegativity difference between a pair of atoms will be the surest predictor of the degree of ionicity of the bond.^[67]

The third of the topics that Pauling attacked under the overall heading of "the nature of the chemical bond" was the accounting of the structure of aromatic hydrocarbons, particularly the prototype, benzene.^[68] The best description of benzene had been made by the German chemist Friedrich Kekulé. He had treated it as a rapid interconversion between two structures, each with alternating single and double bonds, but with the double bonds of one structure in the locations where the single bonds were in the other. Pauling showed that a proper description based on quantum mechanics was an intermediate structure which was a blend of each. The structure was a superposition of structures rather than a rapid interconversion between them. The name "resonance" was later applied to this phenomenon.^[69] In a sense, this phenomenon resembles that of hybridization, described earlier, because it involves combining more than one electronic structure to achieve an intermediate result.

[edit] Structure of the atomic nucleus

On September 16, 1952, Pauling opened a new research notebook with these words "I have decided to attack the problem of the structure of nuclei."^[70] On October 15, 1965, Pauling published his Close-Packed Spheron Model of the atomic nucleus in two well respected journals, Science, and Proc. Natl. Acad. Sci..^[71] For nearly three decades, until his death in 1994, Pauling published numerous papers on his spheron cluster model.^{[72][73][74][75][76][77]}

Few modern text books on nuclear physics discuss the Pauling Spheron Model of the Atomic Nucleus, yet it provides a unique perspective, well published in the leading journals of science, on how fundamental "clusters of nucleons" can form shell structure in agreement with recognized theory of quantum mechanics. Pauling was well versed in quantum mechanics; he co-authored one of the first textbooks on the subject, Introduction to Quantum Mechanics with Applications to Chemistry. In a 2006 review of models of atomic nuclei, Norman D. Cook said of the Pauling Spheron Model: "?the model leads to a rather common-sense molecular build-up of nuclei and has an internal logic that is hard to deny?however?nuclear theorists have not elaborated on the idea of nucleon spherons, and Pauling's model has not entered mainstream nuclear theory."^[78] Taken at face value, the conclusions of Norman Cook imply that the 1965 Pauling Spheron Model of the atomic nucleus has not been replaced by a better model, but has simply been ignored.

The Pauling spheron nucleon clusters include the deuteron[NP], helion [PNP], and triton [NPN]. Even-even nuclei were described as being composed of clusters of alpha particles, as has often been done for light nuclei. He made an effort to derive the shell structure of nuclei from the Platonic solids rather than starting from an independent particle model as in the usual shell model. It was sometimes said at that time that this work received more attention than it would have if it had been done by a less famous person, but more likely Pauling was taking a unique approach to understanding the relatively new discovery in the late 1940s of Maria Goeppert-Mayer of structure within the nucleus. In an interview Pauling commented on his model:^[79]

“

Now recently, I have been trying to determine detailed structures of atomic nuclei by analyzing the ground state and excited state vibrational bends, as observed experimentally. From reading the physics literature, Physical Review Letters and other journals, I know that many physicists are interested in atomic nuclei, but none of them, so far as I have been able to discover, has been attacking the problem in the same way that I attack it. So I just move along at my own speed, making calculations?

”

[edit] Legacy

Pauling died of prostate cancer on August 19, 1994, at 7:20 PM at home in Big Sur, California. He was 93 years old.^[80][81] A grave marker for him is in Oswego Pioneer Cemetery in Lake Oswego, Oregon.^[81][82]

Pauling was included in a list of the 20 greatest scientists of all time by the magazine New Scientist, with Albert Einstein being the only other scientist from the twentieth century on the list. Gautam R. Desiraju, the author of the Millennium Essay in Nature,^[83] claimed that Pauling was one of the greatest thinkers and visionaries of the millennium, along with Galileo, Newton, and Einstein. Pauling is notable for the diversity of his interests: quantum mechanics, inorganic chemistry, organic chemistry, protein structure, molecular biology, and medicine. In all these fields, and especially on the boundaries between them, he made decisive contributions. His work on chemical bonding marks the beginning of modern quantum chemistry, and many of his contributions like hybridization and electronegativity have become part of standard chemistry textbooks. His valence bond approach fell short of accounting quantitatively for some of the characteristics of molecules, such as the paramagnetic nature of oxygen and the color of organometallic complexes, and would later be superseded by the Molecular Orbital Theory of Robert Mulliken. However, the Valence Bond theory still exists in its modern form and competes with the Molecular Orbital Theory and Density Functional Theory (DFT) for describing the chemical phenomena.^[84] Pauling's work on crystal structure contributed significantly to the prediction and elucidation of the structures of complex minerals and compounds.^{[citation needed]} His discovery of the alpha helix and beta sheet is a fundamental foundation for the study of protein structure.^{[citation needed]}

Francis Crick acknowledged Pauling as the "father of molecular biology"^{[cite this quote]}. His discovery of sickle cell anemia as a "molecular disease" opened the way toward examining genetically acquired mutations at a molecular level.^{[citation needed]}

Pauling's protegé, Dr. Mathias Rath, M.D., continued his early works into cellular medicine, expanding the volumes of data about natural substances related in disease prevention and alleviation. Pauling's stand led these subjects to be much more actively investigated by other researchers, including those at the Linus Pauling Institute, which lists a dozen principal investigators and faculty who study the role of micronutrients and phytochemicals in health and disease.

Items named after Pauling include Linus and Eva Helen Pauling Hall at Soka University of America in Aliso Viejo, California, Linus Pauling Middle School in Corvallis, Oregon, and Pauling Field a small airfield located in Condon, Oregon. Dr. Pauling spent his youth in Condon.

Linus Torvalds, developer of the Linux kernel, is named after Pauling.^[85]

On March 6, 2008, the United States Postal Service released a 41 cent stamp honoring Pauling.^[86] His description reads: "A remarkably versatile scientist, structural chemist Linus Pauling (1901-1994) won the 1954 Nobel Prize in Chemistry for determining the nature of the chemical bond linking atoms into molecules. His work in establishing the field of molecular biology; his studies of hemoglobin led to the classification of sickle cell anemia as a molecular disease." The other scientists on this sheet include Gerty Cori, biochemist, Edwin Hubble, astronomer, and John Bardeen, physicist.

California Governor Arnold Schwarzenegger and First Lady Maria Shriver announced on May 28, 2008 that Pauling would be inducted into the California Hall of Fame, located at The California Museum for History, Women and the Arts. The induction ceremony was scheduled to take place December 15, 2008. Pauling's son was asked to accept the honor in his place.

Pauling appears in the 2006 novel Visibility by Boris Starling, who later named his son Linus.

[edit] Honors and awards

Pauling received numerous awards and honors during his career. Following are awards and honors he has received.

[edit] Publications

• Pauling, L. The Nature of the Chemical Bond. Cornell University Press ISBN 0-8014-0333-2
  • Manuscript notes and typescripts (clear images)
• Pauling, L., and Wilson, E. B. Introduction to Quantum Mechanics with Applications to Chemistry (Dover Publications) ISBN 0-486-64871-0
• Pauling, L. Vitamin C, the Common Cold and the Flu (W.H. Freeman and Company) ISBN 0-7167-0360-2
• Cameron E. and Pauling, L. Cancer and Vitamin C: A Discussion of the Nature, Causes, Prevention, and Treatment of Cancer With Special Reference to the Value of Vitamin C (Camino Books) ISBN 0-940159-21-X
• Pauling, L. How to Live Longer and Feel Better (Avon Books) ISBN 0-380-70289-4
• Pauling, L. Linus Pauling On Peace - A Scientist Speaks Out on Humanism and World Survival (Rising Star Press) ISBN 0-933670-03-6
• Pauling, L. General Chemistry (Dover Publications) ISBN 0-486-65622-5
• A Lifelong Quest for Peace with Daisaku Ikeda
• Pauling, L. The Architecture of Molecules
• Pauling, L. No More War!

[edit] See also

• 1920 US Census with Pauling in Portland, Oregon

[edit] Notes

[edit] References