Anorexia nervosa

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For other uses, see Anorexia nervosa (disambiguation).
Anorexia Nervosa
Classification and external resources
ICD-10 F50.0-F50.1
ICD-9 307.1
OMIM 606788
DiseasesDB 749
eMedicine emerg/34  med/144

Anorexia nervosa is a psychiatric illness that describes an eating disorder characterized by extremely low body weight and body image distortion with an obsessive fear of gaining weight. Individuals with anorexia are known to control body weight commonly through the means of voluntary starvation, purging, excessive exercise or other weight control measures such as diet pills or diuretic drugs. While the condition primarily affects adolescent females approximately 10% of people with the diagnosis are male[1]. Anorexia nervosa, involving neurobiological, psychological, and sociological components[2] is a complex condition that can lead to death in severe cases.

The term anorexia is of Greek origin: a (α, prefix of negation), n (ν, link between two vowels) and orexis (ορεξις, appetite), thus meaning a lack of desire to eat.[3]

"Anorexia nervosa" is frequently shortened to "anorexia" in the popular media. This is technically incorrect as the term "anorexia" may be misinterpreted as a symptom of reduced appetite while the medical condition is technically called anorexia nervosa. There is no definition to "nervosa" in the English language. Bulimia nervosa is a related condition to anorexia nervosa. Orthorexia nervosa may be added to the DSM, but is currently a psychological illness that has been coined by Steven Bratman, a Colorado MD. .[4] Argyreia nervosa, Mahonia nervosa, Utricularia nervosa and Lettsomia nervosa are all unrelated genus and species names for plants.

Contents

[edit] Diagnosis and clinical features

Established by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) and the World Health Organization's International Statistical Classification of Diseases and Related Health Problems (ICD).

Although biological tests can aid the diagnosis of anorexia, the diagnosis is based on a combination of behavior, reported beliefs and experiences, and physical characteristics of the patient. Anorexia is typically diagnosed by a clinical psychologist, psychiatrist or other suitably qualified clinician. Notably, diagnostic criteria are intended to assist clinicians, and are not intended to be representative of what an individual sufferer feels or experiences in living with the illness.

The full ICD-10 diagnostic criteria for anorexia nervosa can be found here, and the DSM-IV-TR criteria can be found here.

be diagnosed as having anorexia nervosa, according to the DSM-IV-TR, a person must display:

  1. Refusal to maintain body weight at or above a minimally normal weight for age and height: weight loss leading to maintenance of body weight <85% of that expected or failure to make expected weight gain during period of growth, leading to body weight less than 85% of that expected.
  2. Intense fear of gaining weight or becoming fat, even though under weight.
  3. Disturbance in the way in which one's body weight or shape is experienced, undue influence of body weight or shape on self-evaluation, or denial of the seriousness of the current low body weight.
  4. The absence of at least three consecutive menstrual cycles (amenorrhea) in women who have had their first menstrual period but have not yet gone through menopause (postmenarcheal, premenopausal females).


Furthermore, the DSM-IV-TR specifies two subtypes:

  • Restricting Type: during the current episode of anorexia nervosa, the person has not regularly engaged in binge-eating or purging behavior (that is, self-induced vomiting, over-exercise or the misuse of laxatives, diuretics, or enemas)
  • Binge-Eating Type or Purging Type: during the current episode of anorexia nervosa, the person has regularly engaged in binge-eating OR purging behavior (that is, self-induced vomiting, over-exercise or the misuse of laxatives, diuretics, or enemas).

The ICD-10 criteria are similar, but in addition, specifically mention

  1. The ways that individuals might induce weight-loss or maintain low body weight (avoiding fattening foods, self-induced vomiting, self-induced purging, excessive exercise, excessive use of appetite suppressants or diuretics).
  2. Certain physiological features, including "widespread endocrine disorder involving hypothalamic-pituitary-gonadal axis is manifest in women as amenorrhoea and in men as loss of sexual interest and potency. There may also be elevated levels of growth hormones, raised cortisol levels, changes in the peripheral metabolism of thyroid hormone and abnormalities of insulin secretion".
  3. If onset is before puberty, that development is delayed or arrested.

[edit] Presentation

There are a number of features that, although not necessarily diagnostic of anorexia, have been found to be commonly (but not exclusively) present in those with this eating disorder.[5][2]

[edit] Physical

Changes in brain structure and function are early signs often to be associated with starvation, and is partially reversed when normal weight is regained.[6] Anorexia is also linked to reduced blood flow in the temporal lobes, although since this finding does not correlate with current weight, it is possible that it is a risk trait rather than an effect of starvation.[7]


  • Extreme weight loss
  • Body mass index less than 17.5 in adults, or 85% of expected weight in children
  • Stunted growth
  • Endocrine disorder, leading to cessation of periods in girls (amenorrhoea)
  • Decreased libido; impotence in males
  • Starvation symptoms, such as reduced metabolism, slow heart rate (bradycardia), hypotension, hypothermia and anemia
  • Abnormalities of mineral and electrolyte levels in the body
  • Thinning of the hair
  • Growth of lanugo hair over the body
  • Constantly feeling cold
  • Zinc deficiency
  • Reduction in white blood cell count
  • Reduced immune system function
  • Pallid complexion and sunken eyes
  • Creaking joints and bones
  • Collection of fluid in ankles during the day and around eyes during the night
  • Tooth decay
  • Constipation
  • Dry skin
  • Dry or chapped lips
  • Poor circulation, resulting in common attacks of 'pins and needles' and purple extremities
  • In cases of extreme weight loss, there can be nerve deterioration, leading to difficulty in moving the feet
  • Headaches
  • Brittle fingernails
  • Bruising easily
  • Fragile appearance; frail body image
  • Slowing of the rate of growth of breasts
  • Drastic changes in blood pressure upon standing
  • Dizzyness and fainting

[edit] Psychological

  • Distorted body image
  • Poor insight
  • Self-evaluation largely, or even exclusively, in terms of their shape and weight
  • Pre-occupation or obsessive thoughts about food and weight
  • Perfectionism
  • Obsessive compulsive disorder (OCD)
  • Belief that control over food/body is synonymous with being in control of one's life
  • Refusal to accept that one's weight is dangerously low even when it could be deadly
  • Refusal to accept that one's weight is normal, or healthy

[edit] Emotional

[edit] Behavioral

  • Excessive exercise, food restrictions
  • Secretive about eating or exercise behavior
  • Self-harm, substance abuse
  • Thoughts of suicide
  • Very sensitive to references about body weight
  • Aggressive when forced to eat
  • Social withdraw or being anti-social
  • Checking body in the mirror constantly
  • Checking body weight on scale constantly

[edit] Diagnostic issues and controversies

The distinction between the diagnoses of anorexia nervosa, bulimia nervosa and eating disorder not otherwise specified (EDNOS) is often difficult to make in practice and there is considerable overlap between patients diagnosed with these conditions. Furthermore, seemingly minor changes in a patient's overall behavior or attitude (such as reported feeling of 'control' over any binging behavior) can change a diagnosis from 'anorexia: binge-eating type' to bulimia nervosa. It is not unusual for a person with an eating disorder to 'move through' various diagnoses as his or her behavior and beliefs change over time.[5]

Additionally, it is important to note that an individual may still suffer from a health- or life-threatening eating disorder (e.g., sub-clinical anorexia nervosa or EDNOS) even if one diagnostic sign or symptom is still present. For example, a substantial number of patients diagnosed with EDNOS meet all criteria for diagnosis of anorexia nervosa, but lack the three consecutive missed menstrual cycles needed for a diagnosis of anorexia.[2]

Feminist writers such as Susie Orbach and Naomi Wolf have criticized the medicalization of extreme dieting and weight-loss as locating the problem within the affected women, rather than in a society that imposes concepts of unreasonable and unhealthy thinness as a measure of female beauty.

A vigorous debate exists on the topic of whether eating disorders are a choice or a biological illness. In 2006, Dr. Thomas Insel, director of the US National Institute of Mental Health, wrote an open letter to the National Eating Disorder Association stating "[http://www.nationaleatingdisorders.org/nedaDir/files/documents/NIMHLetter.pdf eating disorders are brain disorders.".

[edit] Causes and contributory factors

It is clear that there is no single cause for anorexia and that it stems from a mixture of biological, social and psychological factors. Current research is commonly focused on explaining existing factors and uncovering new causes. However, there is considerable debate over how much each of the known causes contributes to the development of anorexia, in particular, the contribution of perceived media pressure on women to be thin has been especially contentious.[8]

[edit] Physiological factors

[edit] Genetic factors

Family and twin studies have suggested that genetic factors contribute to about 50% of the variance for the development of an eating disorder[9] and that anorexia shares a genetic risk with clinical depression.[10]. This evidence suggests that genes influencing both eating regulation, and personality and emotion, may be important contributing factors. In one study, variations in the norepinephrine transporter gene promoter were associated with restrictive anorexia nervosa, but not binge-purge anorexia (though the latter may have been due to small sample size).[11]

Several rodent models of anorexia have been developed which largely involve subjecting the animals to various environmental stressors or using gene knockout mice to test hypotheses about the effects of certain genes.[12] These models have suggested that the hypothalamic-pituitary-adrenal axis may be a contributory factor. Although the models have been criticised as food is being limited by the experimenter and not the animal, these models cannot take into account the complex cultural factors known to affect the development of anorexia nervosa.

[edit] Neurobiological factors

There are strong correlations between the neurotransmitter serotonin and various psychological symptoms such as mood, sleep, emesis (vomiting), sexuality and appetite. A recent review of the scientific literature has suggested that anorexia is linked to a disturbed serotonin system,[13] particularly to high levels at areas in the brain with the 5HT1A receptor - a system particularly linked to anxiety, mood and impulse control. Starvation has been hypothesised to be a response to these effects as it is known to lower tryptophan and steroid hormone metabolism. This in turn might reduce serotonin levels at these critical sites and hence ward off anxiety. In contrast, studies of the 5HT2A serotonin receptor (linked to regulation of feeding, mood and anxiety), suggest that serotonin activity is decreased at these sites. However, one difficulty with this work is that it is sometimes difficult to separate cause and effect. These disturbances to brain neurochemistry may be as much the result of starvation rather than continuously existing traits that might predispose someone to develop anorexia. There is evidence that both personality characteristics (such as anxiety and perfectionism) and disturbances to the serotonin system are still apparent after patients have recovered from anorexia,[14] suggesting that these disturbances are likely to be causal risk factors.

Recent studies also suggest anorexia may be linked to an autoimmune response to melanocortin peptides which influence appetite and stress responses. [15]

[edit] Nutritional factors

Zinc deficiency causes a decrease in appetite that can degenerate in anorexia nervosa (AN), appetite disorders and, notably, inadequate zinc nutriture. The use of zinc in the treatment of anorexia nervosa has been advocated since 1979 by Bakan. At least five trials showed that zinc improved weight gain in anorexia. A 1994 randomized, double-blind, placebo-controlled trial showed that zinc (14 mg per day) doubled the rate of body mass increase in the treatment of AN.[16] Deficiency of other nutrients such as tyrosine and tryptophan (precursors of the monoamine neurotransmitters norepinephrine and serotonin, respectively), as well as vitamin B1 (thiamine) could contribute to this phenomenon of malnutrition-induced malnutrition.[16]

[edit] Psychological factors

There has been a significant amount of work into psychological factors that suggests how biases in thinking and perception help maintain or contribute to the risk of developing anorexia.

Anorexic eating behavior is thought to originate from feelings of fatness and unattractiveness[17] and is maintained by various cognitive biases that alter how the affected individual evaluates and thinks about their body, food and eating.

One of the most well-known findings is that people with anorexia tend to over-estimate the size or fatness of their own bodies. A recent review of research in this area suggests that this is not a perceptual problem, but one of how the perceptual information is evaluated by the affected person.[18] Recent research suggests people with anorexia nervosa may lack a type of overconfidence bias in which the majority of people feel themselves more attractive than others would rate them. In contrast, people with anorexia nervosa seem to more accurately judge their own attractiveness compared to unaffected people, meaning that they potentially lack this self-esteem boosting bias.[19]

People with anorexia have been found to have certain personality traits that are thought to predispose them to develop eating disorders. Hilde Bruch's [20] 1973 book Eating Disorders: Obesity, Anorexia Nervosa, and the Person Within emphasized "fear of being despised" and perfectionism as the basis for Anorexia Nervosa, and influenced theories for the next three decades. However, subsequent research has not revealed a unique, consistent personality among victims. High levels of obsession (being subject to intrusive thoughts about food and weight-related issues), restraint (being able to fight temptation), and clinical levels of perfectionism (the pathological pursuit of personal high-standards and the need for control) have been cited as commonly reported factors in research studies.[21]

It is often the case that other psychological difficulties and mental illnesses exist alongside anorexia nervosa in the sufferer. Clinical depression, obsessive compulsive disorder, substance abuse and one or more personality disorders are the most likely conditions to be comorbid with anorexia, and high-levels of anxiety and depression are likely to be present regardless of whether they fulfill diagnostic criteria for a specific syndrome.[22]

Research into the neuropsychology of anorexia has indicated that many of the findings are inconsistent across studies and that it is hard to differentiate the effects of starvation on the brain from any long-standing characteristics. Nevertheless, one reasonably reliable finding is that those with anorexia have poor cognitive flexibility[23] (the ability to change past patterns of thinking, particularly linked to the function of the frontal lobes and executive system).

Other studies have suggested that there are some attention and memory biases that may maintain anorexia.[24] Attentional biases seem to focus particularly on body and body-shape related concepts which makes them more salient for those affected by the condition. Some limited studies have found that those with anorexia may be more likely to recall related material than unrelated material.

Fairburn and colleagues psychological model of anorexia

Although there has been quite a lot of research into psychological factors there are relatively few hypotheses which attempt to explain the condition as a whole.

Professor Chris Fairburn, of the University of Oxford and his colleagues have created a 'transdiagnostic' model,[25] in which they aim to explain how anorexia, as well as related disorders such as bulimia nervosa and ED-NOS, are maintained. Their model is developed with psychological therapies, particularly cognitive behavioral therapy, in mind, and so suggests areas where clinicians could provide psychological treatment.

Their model is based on the idea that all major eating disorders (with the exception of obesity) share some core types of psychopathology which help maintain the eating disorder behavior. This includes clinical perfectionism, chronic low self-esteem, mood intolerance (inability to cope appropriately with certain emotional states) and interpersonal difficulties.

[edit] Social and environmental factors

Sociocultural studies have highlighted the role of cultural factors, particularly through the media, such as the promotion of thinness as the ideal female form in Western industrialised nations. A recent epidemiological study of 989,871 Swedish residents indicated that gender, ethnicity and socio-economic status were large influences on the chance of developing anorexia. Those with non-European parents were among the least likely to be diagnosed with the condition and those in wealthy, white families being most at risk.[26] A classic study by Garner and Garfinkel demonstrated that those in professions where there is a particular social pressure to be thin (such as models and dancers) were much more likely to develop anorexia during the course of their career,[27] and further research has suggested that those with anorexia have much higher contact with cultural sources that promote weight-loss.[28]

Although anorexia nervosa is usually associated with Western cultures, exposure to Western media is thought to have led to an increase in cases in non-Western countries. However, it is notable that other cultures may not display the same 'fat phobic' worries about becoming fat as those with the condition in the West, and instead may present with low appetite with the other common features.[29]

There is a high rate of reported child sexual abuse experiences in clinical groups of who have been diagnosed with anorexia (up to 50% in those admitted to inpatient wards, with a lesser prevalence among people treated in the community). Although prior sexual abuse is not thought to be a specific risk factor for anorexia, those who have experienced such abuse are more likely to have more serious and chronic symptoms.[30]

The Internet has enabled anorexics and bulimics to contact and communicate with each other outside of a treatment environment, with much lower risks of rejection by mainstream society. A variety of websites exist, some run by sufferers, some by former sufferers, and some by professionals. The majority of such sites support a medical view of anorexia as a disorder to be cured, although some people affected by anorexia have formed online pro-ana communities that reject the medical view and argue that anorexia is a 'lifestyle choice', using the internet for mutual support, and to swap weight-loss tips.[31] Such websites were the subject of significant media interest, largely focusing on concerns that these communities could encourage young women to develop or maintain eating disorders, and many were taken offline as a result.[32]

[edit] Prognosis

Anorexia is thought to have the highest mortality rate of any psychiatric disorder, with approximately 6% of those who are diagnosed with the disorder eventually die due to related causes.[33] The suicide rate of people with anorexia is also higher than that of the general population and is thought to be the major cause of death for those with the condition.[34]

[edit] Incidence, prevalence and demographics

The majority of research into the incidence and prevalence of anorexia has been done in Western industrialized countries, so results are generally not applicable outside these areas. However, recent reviews[35][36] of studies on the epidemiology of anorexia have suggested an incidence of between 8 and 13 cases per 100,000 persons per year and an average prevalence of 0.3% using strict criteria for diagnosis. These studies also confirm the view that the condition largely affects young adolescent females, with females between 15 and 19 years old making up 40% of all cases. Furthermore, the majority of cases are unlikely to be in contact with mental health services. As a whole, about 10% of people with anorexia are male and about 90% of people with anorexia are female.[2] Anorexia, however, is not exclusively limited to any age or demographic. In March 2008, a British senior university lecturer with PhD in psychology and a professional background in health, Rosemary Pope, died from anorexia.[37] Anorexia has been reported occurring throughout a patient's life extending into the seventies and eighties.[38] In addition, onset can occur in one's sixties or later.[39] The Italian character actor, Giovanni Rovini, died of onset of symptoms commencing in his early nineties. [40]

[edit] Treatment

The first line treatment for anorexia is usually focused on immediate weight gain, especially with those who have particularly serious conditions that require hospitalization. In particularly serious cases, this may be done as an involuntary hospital treatment under mental health law, where such legislation exists. However, in the majority of cases people with anorexia are treated as outpatients with input from physicians, psychiatrists, clinical psychologists and other mental health professionals.

A recent clinical review has suggested that psychotherapy is an effective form of treatment and can lead to restoration of weight, return of menses among female patients, and improved psychological and social functioning when compared to simple support or education programmes.[41] However, this review also noted that there are only a small number of randomised controlled trials on which to base this recommendation, and no specific type of psychotherapy seems to show any overall advantage when compared to other types. Family therapy has also been found to be an effective treatment for adolescents with anorexia[42] and in particular, a method developed at the Maudsley Hospital is widely used and found to maintain improvement over time.[43]

Drug treatments, such as SSRI or other antidepressant medication, have not been found to be generally effective for either treating anorexia,[44] or preventing relapse[45] although it has also been noted that there is a lack of adequate research in this area. It is common, however, for antidepressants to be prescribed, often with the intent of trying to treat the associated anxiety and depression.

Supplementation with 14mg/day of zinc is recommended as routine treatment for anorexia nervosa due to a study showing a doubling of weight regain after treatment with zinc was begun. The mechanism of action is hypothesized to be an increased effectiveness of neurotransmission in various parts of the brain, including the amygdala, after adequate zinc intake begins resulting in increased appetite.[46]

There are various non-profit and community groups that offer support and advice to people who suffer from anorexia or who care for someone who does.

[edit] See also

[edit] References

  1. ^ "The Numbers Count: Mental Disorders in America". The National Institute of Mental Health. http://www.nimh.nih.gov/health/publications/the-numbers-count-mental-disorders-in-america.shtml#Eating. Retrieved on 2008-10-09. 
  2. ^ a b c d Lask B, and Bryant-Waugh, R (eds) (2000) Anorexia Nervosa and Related Eating Disorders in Childhood and Adolescence. Hove: Psychology Press. ISBN 0-86377-804-6.
  3. ^ Costin, Carolyn.~ (1999) The Eating Disorder Sourcebook. Linconwood: Lowell House. 6.
  4. ^ Bratman, Steven.~ (2003)Who is Steven Bratman?http://www.orthorexia.com/index.php?page=Bratman
  5. ^ a b Gowers S, Bryant-Waugh R. (2004) Management of child and adolescent eating disorders: the current evidence base and future directions. J Child Psychol Psychiatry, 45 (1), 63-83. PMID 14959803
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  9. ^ Klump KL, Kaye WH, Strober M (2001) The evolving genetic foundations of eating disorders. Psychiatr Clin North Am, 24 (2), 215-25. PMID 11416922.
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  11. ^ Urwin, R.E., Bennetts, B., Wilcken, B. et al. (2002). "Anorexia nervosa (restrictive subtype) is associated with a polymorphism in the novel norepinephrine transporter gene promoter polymorphic region," Molecular Psychiatry, 7(6), 652–657.
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  20. ^ http://en.wikipedia.org/wiki/Hilde_bruch
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  32. ^ Reaves, J. (2001). Anorexia goes high tech. Time (July). Retrieved on April 16, 2007.
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  37. ^ "Professor, 49, died from anorexia". BBC. 2008-04-22. http://news.bbc.co.uk/2/hi/uk_news/england/dorset/7360470.stm. Retrieved on 2008-04-23. 
  38. ^ AJ Giannini, N Telew. Anorexia nervosa in geriatric patienys. Geriatric Medicine Today. 6:75-78, 1987.
  39. ^ AJ Giannini. Drug abuse and depression:possible models for geriatric anorexia. Neurobiology of Aging. 9:26-27, 1988.
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  41. ^ Hay P, Bacaltchuk J, Claudino A, Ben-Tovim D, Yong PY. (2003) Individual psychotherapy in the outpatient treatment of adults with anorexia nervosa. Cochrane Database Syst Rev, 4, CD003909. PMID 14583998.
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  43. ^ Le Grange D. (2005) The Maudsley family-based treatment for adolescent anorexia nervosa. World Psychiatry, 4 (3), 142-6. PMID 16633532.
  44. ^ Claudino AM, Hay P, Lima MS, Bacaltchuk J, Schmidt U, Treasure J. (2006) Antidepressants for anorexia nervosa. Cochrane Database Syst Rev, 1, CD004365. PMID 16437485.
  45. ^ Walsh BT, Kaplan AS, Attia E, Olmsted M, Parides M, Carter JC, Pike KM, Devlin MJ, Woodside B, Roberto CA, Rockert W. (2006) Fluoxetine after weight restoration in anorexia nervosa: a randomized controlled trial. JAMA, 295(22), 2605-12. PMID 16772623.
  46. ^ Birmingham CL, Gritzner S (2006) How does zinc supplementation benefit anorexia nervosa? Eating and Weight Disorders, 11 (4), e109-111. PMID 17272939

[edit] External links

[edit] Informational resources

[edit] Media stories and reports

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