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Dementia Classification and external resources
ICD-10	F00.-F07.
ICD-9	290-294
DiseasesDB	29283
MedlinePlus	000739
MeSH	D003704

Dementia (from Latin de- "apart, away" + mens "mind") is the progressive decline in cognitive function due to damage or disease in the body beyond what might be expected from normal aging. Although dementia is far more common in the geriatric population, it may occur in any stage of adulthood. This age cutoff is defining, as similar sets of symptoms due to organic brain dysfunction are given different names in populations younger than adulthood (see, for instance, developmental disorders).

Dementia is a non-specific illness syndrome (set of signs and symptoms) in which affected areas of cognition may be memory, attention, language, and problem solving. Higher mental functions are affected first in the process. Especially in the later stages of the condition, affected persons may be disoriented in time (not knowing what day of the week, day of the month, or even what year it is), in place (not knowing where they are), and in person (not knowing who they are or others around them).

Symptoms of dementia can be classified as either reversible or irreversible, depending upon the etiology of the disease. Less than 10 percent of cases of dementia are due to causes which may presently be reversed with treatment. Causes include many different specific disease processes, in the same way that symptoms of organ dysfunction such as shortness of breath, jaundice, or pain are attributable to many etiologies. Without careful assessment of history, the short-term syndrome of delirium can easily be confused with dementia, because they have many symptoms in common. Some mental illnesses, including depression and psychosis, may also produce symptoms which must be differentiated from both delirium and dementia.^[1]

Contents 1 Diagnosis 1.1 Mini-mental state examination 1.2 Modified Mini-Mental State examination (3MS) 1.3 Abbreviated mental test score 1.4 Other examinations 1.5 Laboratory tests 1.6 Imaging 2 Types 2.1 Cortical dementias 2.2 Subcortical dementias 3 Treatment 3.1 Medications 3.1.1 Off label 3.2 Contraindicated 4 Prevention 5 Risk to self and others 6 Services 7 See also 8 References 8.1 Notes 8.2 External links

[edit] Diagnosis

Proper differential diagnosis between the types of dementia (cortical and subcortical - see below) will require, at the least, referral to a specialist, e.g. a geriatric internist, geriatric psychiatrist, neurologist, neuropsychologist or geropsychologist.^{[citation needed]} However, there exist some brief tests (5–15 minutes) that have reasonable reliability and can be used in the office or other setting to screen cognitive status for deficits which are considered pathological. Examples of such tests include the abbreviated mental test score (AMTS), the mini mental state examination (MMSE), Modified Mini-Mental State Examination (3MS),^[2] the Cognitive Abilities Screening Instrument (CASI),^[3] and the clock drawing test.^[4] An AMTS score of less than six (out of a possible score of ten) and an MMSE score under 24 (out of a possible score of 30) suggests a need for further evaluation. Scores must be interpreted in the context of the person's educational and other background, and the particular circumstances; for example, a person highly depressed or in great pain will not be expected to do well on many tests of mental ability.

[edit] Mini-mental state examination

The U.S. Preventive Services Task Force (USPSTF) reviewed tests for cognitive impairment and concluded:^[5]

• MMSE

sensitivity 71% to 92%

specificity 56% to 96%

[edit] Modified Mini-Mental State examination (3MS)

A copy of the 3MS is online.^[6] A meta-analysis concluded that the Modified Mini-Mental State (3MS) examination has:^[7]

sensitivity 83% to 93.5%

specificity 85% to 90%

[edit] Abbreviated mental test score

A meta-analysis concluded:^[7]

sensitivity 73% to 100%

specificity 71% to 100%

[edit] Other examinations

Many other tests have been studied^[8][9][10] including the clock-drawing test (example form). Although some may emerge as better alternatives to the MMSE, presently the MMSE is the best studied. However, access to the MMSE is now limited by enforcement of its copyright.^{[citation needed]}

Another approach to screening for dementia is to ask an informant (relative or other supporter) to fill out a questionnaire about the person's everyday cognitive functioning. Informant questionnaires provide complementary information to brief cognitive tests. Probably the best known questionnaire of this sort is the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE).^[11]

Further evaluation includes retesting at another date, and administration of other (and sometimes more complex) tests of mental function, such as formal neuropsychological testing.

[edit] Laboratory tests

Routine blood tests are also usually performed to rule out treatable causes. These tests include vitamin B12, folic acid, thyroid-stimulating hormone (TSH), C-reactive protein, full blood count, electrolytes, calcium, renal function, and liver enzymes. Abnormalities may suggest vitamin deficiency, infection or other problems that commonly cause confusion or disorientation in the elderly. The problem is complicated by the fact that these cause confusion more often in persons who have early dementia, so that "reversal" of such problems may ultimately only be temporary.

Chronic use of substances such as alcohol can also predispose the patient to cognitive changes suggestive of dementia.

[edit] Imaging

A CT scan or magnetic resonance imaging (MRI scan) is commonly performed, although these modalities (as is noted below) do not have optimal sensitivity for the diffuse metabolic changes associated with dementia in a patient who shows no gross neurological problems (such as paralysis or weakness) on neurological exam. CT or MRI may suggest normal pressure hydrocephalus, a potentially reversible cause of dementia, and can yield information relevant to other types of dementia, such as infarction (stroke) that would point at a vascular type of dementia. However, the functional neuroimaging modalities of SPECT and PET have shown similar ability to diagnose dementia as clinical exam.^[12] The ability of SPECT to differentiate the vascular cause from the Alzheimer disease cause of dementias, appears to be superior to differentiation by clinical exam.^[13]

[edit] Types

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[edit] Cortical dementias

Cortical dementias arise from a disorder affecting the cerebral cortex, the outer layers of the brain that play a critical role in cognitive processes such as memory and language.

• Alzheimer's disease
• Vascular dementia (also known as multi-infarct dementia), including Binswanger's disease
• Dementia with Lewy bodies (DLB)
• Alcohol-Induced Persisting Dementia
  • Korsakoff's syndrome
  • Wernicke's encephalopathy
• Frontotemporal lobar degenerations (FTLD), including Pick's disease
  • Frontotemporal dementia (or frontal variant FTLD)
  • Semantic dementia (or temporal variant FTLD)
  • Progressive non-fluent aphasia
• Creutzfeldt-Jakob disease
• Dementia pugilistica
• Moyamoya disease
• Thebestia (Often mistaken for a cancer)
• Posterior cortical atrophy or Benson's syndrome.

[edit] Subcortical dementias

result from dysfunction in the parts of the brain that are beneath the cortex. Usually, the memory loss and language difficulties that are characteristic of cortical dementias are not present. Rather, people with subcortical dementias, such as Huntington's disease, Parkinson's Disease, and AIDS dementia complex, tend to show changes in their personality and attention span, and their thinking slows down.

• Dementia due to Huntington's disease
• Dementia due to Hypothyroidism
• Dementia due to Parkinson's disease
• Dementia due to Vitamin B1 deficiency
• Dementia due to Vitamin B12 deficiency
• Dementia due to Folate deficiency
• Dementia due to Syphilis
• Dementia due to Subdural hematoma
• Dementia due to Hypercalcaemia
• Dementia due to Hypoglycemia
• AIDS dementia complex
• Pseudodementia (a major depressive episode with prominent cognitive symptoms)
• Substance-induced persisting dementia (related to psychoactive use and formerly Absinthism)
• Dementia due to multiple etiologies
• Dementia due to other general medical conditions (i.e. end stage renal failure, cardiovascular disease etc.)
• Dementia not otherwise specified (used in cases where no specific criteria is met)

Dementia and early onset dementia have been associated with neurovisceral porphyrias. Porphyria is listed in textbooks in the differential diagnosis of dementia. Because acute intermittent porphyria, hereditary coproporphyria and variegate porphyria are aggravated by environmental toxins and drugs the disorders should be ruled out when these etiologies are raised.

[edit] Treatment

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Except for the treatable types listed above, there is no cure to this illness, although scientists are progressing in making a type of medication that will slow down the process.^{[citation needed]} Cholinesterase inhibitors are often used early in the disease course. Cognitive and behavioral interventions may also be appropriate. Educating and providing emotional support to the caregiver (or carer) is of importance as well (see also elderly care).

A Canadian study found that a lifetime of bilingualism has a marked influence on delaying the onset of dementia by an average of four years when compared to monolingual patients. The researchers determined that the onset of dementia symptoms in the monolingual group occurred at the mean age of 71.4, while the bilingual group was 75.5 years. The difference remained even after considering the possible effect of cultural differences, immigration, formal education, employment and even gender as influences in the results.^[14]

Some studies worldwide have found that Music therapy may be useful in helping patients with dementia.^{[15][16][17][18][19]}

[edit] Medications

• Acetylcholinesterase inhibitors

Tacrine (Cognex), donepezil (Aricept), galantamine (Razadyne), and rivastigmine (Exelon) are approved by the United States Food and Drug Administration (FDA) for treatment of dementia induced by Alzheimer disease. They may be useful for other similar diseases causing dementia such as Parkinsons or vascular dementia.^[20]

• N-methyl-D-aspartate Blockers. Memantine (Namenda) is a drug representative of this class. It can be used in combination with acetylcholinesterase inhibitors.^{[citation needed]}

[edit] Off label

• Amyloid deposit inhibitors

Minocycline and Clioquinoline, antibiotics, may help reduce amyloid deposits in the brains of persons with Alzheimer disease.^[21]

• Antidepressant drugs

Depression is frequently associated with dementia and generally worsens the degree of cognitive and behavioral impairment. Antidepressants may be helpful in alleviating cognitive and behavior symptoms by reuptaking neurotransmitter regulation through reuptake of serotonin, noradrenaline and dopamine.^{[citation needed]}

• Anxiolytic drugs

Many patients with dementia experience anxiety symptoms. Although benzodiazepines like diazepam (Valium) have been used for treating anxiety in other situations, they are often avoided because they may increase agitation in persons with dementia and are likely to worsen cognitive problems or are too sedating. Buspirone (Buspar) is often initially tried for mild-to-moderate anxiety.^{[citation needed]}

Selegiline, a drug used primarily in the treatment of Parkinson's disease, appears to slow the development of dementia. Selegiline is thought to act as an antioxidant, preventing free radical damage. However, it also acts as a stimulant, making it difficult to determine whether the delay in onset of dementia symptoms is due to protection from free radicals or to the general elevation of brain activity from the stimulant effect.^{[citation needed]}

[edit] Contraindicated

• Antipsychotic drugs

Both typical antipsychotics (such as Haloperidol) and atypical antipsychotics such as (risperidone) increases the risk of death in dementia-associated psychosis.^[22] Antipsychotics are therefore not indicated for the treatment of dementia-related psychosis.^[23]

[edit] Prevention

It appears that the regular moderate consumption of alcohol (beer, wine, or distilled spirits) and a Mediterranean diet may reduce risk.^{[24][25][26][27]} A study has shown a link between high blood pressure and developing dementia. The study, published in the Lancet Neurology journal July 2008, found that blood pressure lowering medication reduced dementia by 13%.^[28][29]

[edit] Risk to self and others

Driving with dementia could lead to severe injury or even death to self and others. Doctors should advise appropriate testing on when to quit driving.^[30]

Florida's Baker Act allows law enforcement and the judiciary to force mental evaluation for those suspected of suffering from dementia or other mental incapacities.^{[citation needed]}

[edit] Services

Adult daycare centers as well as special care units in nursing homes often provide specialized care for dementia patients. Adult daycare centers offer supervision, recreation, meals, and limited health care to participants, as well as providing respite for caregivers.

[edit] See also

• Caregiving and dementia
• Montessori-Based Dementia Programming
• Alcohol dementia
• Sundowning (dementia)
• Wandering (dementia)

[edit] References

[edit] Notes

[edit] External links

• Alzheimer's Disease Research
• Alzheimer's Research Trust - What is dementia? - Information produced by the Alzheimer's Research Trust including statistics.
• Alzheimer's Society - About dementia - Information produced by the Alzheimer's Society including factsheets and support.
• An Documentary About Dementia Produced by Knowledge Network
• [1] Bradford Dementia Group - provide education, training and research on dementia care
• Dementia Research News from ScienceDaily
• The Dementia Services Development Centre, University of Stirling
• Dementia tutorial for U.K. practitioners by the Alzheimer's Society
• Getting Started in Telecare for Patients with DementiaPDF (897 KiB)
• Understanding Dementia: a primer of diagnosis and management
• AlzOnline - AlzOnline provides education, information, and support to persons caring for someone with Alzheimer's disease or a related memory problem.
• CSIP National Older Persons Mental Health Programme Includes an involvement toolkit with tips on how people with dementia can get involved in the planning, development and evaluation of services
• Dementia Advocacy and Support Network
• Dementia Care Mapping Bradford Dementia Group
• Dementia at GPnotebook
• Dementia at eMedicineHealth
• MedlinePlus Overview Dementia
• Merck Geriatrics 5-40a

v • d • e WHO ICD-10 mental and behavioral disorders (F · 290–319) Neurological/symptomatic Dementia (Alzheimer's disease, multi-infarct dementia, Pick's disease, Creutzfeldt-Jakob disease, Huntington's disease, Parkinson's disease, AIDS dementia complex, Frontotemporal dementia, Elopement, Sundowning, Wandering) · Delirium · Post-concussion syndrome · Organic brain syndrome Psychoactive substance alcohol (acute alcohol intoxication, drunkenness, alcohol dependence, alcoholic hallucinosis, Alcohol withdrawal, delirium tremens, Korsakoff's syndrome, alcohol abuse) · opioids (opioid overdose, opioid dependency) · sedative/hypnotic (benzodiazepine overdose, benzodiazepine dependence, benzodiazepine withdrawal) · cocaine (cocaine dependence) · general (Intoxication/Drug overdose, Drug abuse, Physical dependence, Rebound effect, Withdrawal) Schizophrenia, schizotypal and delusional Psychosis (Schizoaffective disorder, Schizophreniform disorder, Brief reactive psychosis) · Schizophrenia (Disorganized schizophrenia, Delusional disorder, Folie à deux) · Personality disorder (Schizotypal personality disorder) Mood (affective) Mania · Bipolar disorder (Bipolar I, Bipolar II, Cyclothymia) · Depression (Major depressive disorder, Dysthymia) Neurotic, stress-related and somatoform Anxiety disorder/ adjustment disorder phobic anxiety disorders: Agoraphobia · Social anxiety/Social phobia (Anthropophobia) · Specific phobia (Claustrophobia) Panic disorder/Panic attack · Generalized anxiety disorder · OCD · stress (Acute stress reaction, PTSD) Somatoform disorder Somatization disorder · Body dysmorphic disorder · Hypochondriasis · Nosophobia · Da Costa's syndrome · Psychalgia · Conversion disorder (Ganser syndrome) · Neurasthenia Dissociative disorder Dissociative identity disorder · Psychogenic amnesia Physiological/physical behavioral Eating disorder Anorexia nervosa · Bulimia nervosa Sleep disorder Dyssomnia (Hypersomnia, Insomnia) · Parasomnia (REM behavior disorder, Night terror) · Nightmare Sexual dysfunction Erectile dysfunction · Premature ejaculation · Vaginismus · Dyspareunia · Hypersexuality · Female sexual arousal disorder Postnatal Postpartum depression · Postnatal psychosis Adult personality and behavior Personality disorder · Impulse control disorder (Kleptomania, Trichotillomania, Pyromania) · Factitious disorder (Munchausen syndrome) · Ego-dystonic sexual orientation · Paraphilia (Voyeurism, Fetishism) Mental disorders diagnosed in childhood Mental retardation X-Linked mental retardation Psychological development (developmental disorder) Specific speech and language (expressive language disorder, aphasia, expressive aphasia, receptive aphasia, Landau-Kleffner syndrome, lisp) · Scholastic skills (dyslexia, dysgraphia, Gerstmann syndrome) · Motor function (developmental dyspraxia) Pervasive Autism · Rett syndrome · Asperger syndrome Behavioral and emotional ADHD · Conduct disorder (ODD) · emotional disorder (Separation anxiety disorder) · social functioning (Selective mutism, RAD, DAD) · Tic disorder (Tourette syndrome) · Speech (Stuttering, Cluttering) · Stereotypic movement disorder