Orthomolecular medicine

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Biologically based alternative
and complementary therapy
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NCCAM classifications
  1. Alternative Medical Systems
  2. Mind-Body Intervention
  3. Biologically Based Therapy
  4. Manipulative Methods
  5. Energy Therapy
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Orthomolecular medicine, or megavitamin therapy, is a form of complementary and alternative medicine that seeks to prevent or treat diseases with nutrients prescribed as dietary supplements or derived from diets.[1][2][3] Orthomolecular medicine focuses on what it sees as the right nutritional molecules in the right amounts for the individual. It often recommends megavitamin doses much larger than those considered medically necessary.[3] In general, the vitamin megadoses advocated by orthomolecular medicine are unsupported by scientific consensus.[4] Some vitamins are toxic in high doses.[5]

The term "orthomolecular" was coined by Nobel laureate Linus Pauling to mean "the right molecules in the right amounts" (ortho is Greek for "right").[6] Pauling theorized that "substances that are normally present in the human body" are necessarily good and can be used at high doses to treat disease. The term is not used in medicine, where clinical use of specific nutrients is considered a form of chemoprevention (to prevent or delay development of disease) or chemotherapy (to treat an existing condition).[7]

Proponents[8] state that nutrient treatments are based on patients' personal biochemistries.[9] Supplements are prescribed at high levels or "megadoses" beyond the Dietary Reference Intake. A 2002 survey found that approximately one in twenty-five US adults uses megadose therapy,[10] a practice particularly common among cancer patients.[11]

Nutrients may be useful in preventing and treating some illnesses,[4] but the broad claims made by advocates of megavitamin therapy are considered unsubstantiated by available medical evidence.[12][13][14][4] Critics have described some aspects of orthomolecular medicine as food faddism or quackery.[15][16][17] Research suggests that some nutritional supplements might be harmful;[18][19][20] several specific vitamin therapies are associated with an increased risk of cancer, heart disease, or death.[21][22][23]


[edit] History and development

In the early 20th century, some doctors hypothesised that vitamins could cure disease, and supplements were prescribed in megadoses by the 1930s.[24] Their effects on health were disappointing, though, and in the 1950s and 60s, nutrition was de-emphasised in standard medical curricula.[24] Orthomolecularists claim several figures from these early days of enthusiasm about nutrition as founders of their movement,[25] although the word "orthomolecular" was coined by Linus Pauling only in 1967.

Amongst the individuals claimed posthumously as orthomolecularists are Max Gerson, who developed a diet that he claimed could treat diseases, but which is now thought to be ineffective and dangerous;[26] and the Shute brothers, who attempted to treat heart disease with vitamin E.[27] Several concepts now claimed by orthomolecularists, including individual biochemical variation[9] and inborn errors of metabolism,[28][24][29] debuted in scientific papers early in the 20th century.

In 1948, William McCormick theorized that vitamin C deficiency played an important role in many diseases and began to use large doses in patients.[30] In the 1950s, Frederick R. Klenner also used vitamin C megadosage as a therapy for a wide range of illnesses, including polio.[31] Irwin Stone claimed organisms that do not synthesise their own vitamin C due to a loss-of-function mutation have a disease he called "hypoascorbemia".[32] This term is not used by the medical community, and the idea of an organism-wide lack of a biosynthetic pathway as a disease was not endorsed by Stone's contemporaries.[33]

In the 1950s, some individuals believed that vitamin deficiencies caused mental illness.[24] Psychiatrists Humphry Osmond and Abram Hoffer gave acute schizophrenics high doses of niacin,[34] while William Kaufman used niacinamide. While niacin has no known efficacy in psychiatric disease, the use of niacin in combination with statins and other medical therapies has become one of several medical treatments for cardiovascular disease.[4][35]

In the late 1960s, Linus Pauling introduced the expression "orthomolecular"[6] to express the idea of the right molecules in the right amounts.[6] Since the first claims of medical breakthroughs with vitamin C by Pauling and others, findings on the health effects of vitamin C have been controversial and contradictory.[36][37] Pauling has been criticised for making overbroad claims.[38]

Later research branched out into nutrients besides niacin and vitamin C, including essential fatty acids.[39]

[edit] Scope

According to Abram Hoffer, orthomolecular medicine does not purport to treat all diseases, nor is it "a replacement for standard treatment. A proportion of patients will require orthodox treatment, a proportion will do much better on orthomolecular treatment, and the rest will need a skillful blend of both."[40] Nevertheless, unsubstantiated claims have been made that nutrients can prevent,[41] treat, and sometimes cure a wide range of medical conditions, including: acne,[42] alcoholism,[43] allergies, arthritis, autism, bee stings, bipolar disorder, burns, cancer,[44][45] the common cold, depression,drug addiction, drug overdose, epilepsy, heart diseases, heavy metal toxicity, acute hepatitis, herpes, hyperactivity, hypertension, hypoglycemia, influenza, learning disabilities, mental and metabolic disorders,[46] migraine, mononucleosis, mushroom poisoning, neuropathy & polyneuritis (including multiple sclerosis), osteoporosis,[47] polio, an hypothesised condition called "pyroluria", radiation sickness, Raynaud's disease, retardation, schizophrenia,[2] shock, skin problems, snakebite, spider bite, tetanus toxin and viral pneumonia.[48]

[edit] Orthomolecular psychiatry

Hoffer believed that particular nutrients could cure mental illness. In the 1950s, he attempted to treat schizophrenia with niacin, although proponents of orthomolecular psychiatry say that the ideas behind their approach predate Hoffer.[49][50] Carl Pfeiffer of the Pfeiffer Treatment Center continued Hoffer’s approach, believing that for “every drug that benefits a patient, there is a natural substance that can achieve the same effect".[51] According to Hoffer and others who called themselves "orthomolecular psychiatrists", psychiatric syndromes result from biochemical deficiencies, allergies, toxicities or several hypothetical contributing conditions which they termed pyroluria, histadelia and histapenia. These purported causes are said to be found during an "individual biochemical workup" and treated with megavitamin therapy and dietary changes including fasting.[52] These diagnoses and treatments are not accepted by evidence-based medicine.[53]

[edit] Principles

According to Abram Hoffer, "primitive" peoples do not consume processed foods and do not have "degenerative" diseases.[54] In contrast, typical "Western" diets are said to be insufficient for long-term health, necessitating the use of megadose supplements of vitamins, dietary minerals, proteins, antioxidants, amino acids, ω-3 fatty acids, ω-6 fatty acids, medium chain triglycerides, dietary fiber, short and long chain fatty acids, lipotropes, systemic and digestive enzymes, other digestive factors, and prohormones to ward off hypothetical metabolism anomalies at an early stage, before they cause disease.[40]

Orthomolecularists say that they provide prescriptions for optimal amounts of micronutrients after individual diagnoses based on blood tests and personal histories. Lifestyle and diet changes may also be recommended. The battery of tests ordered includes many that are not considered useful by medicine.[citation needed]

[edit] Prevalence

Orthomolecular medicine is practiced by few medical practitioners,[55][56] but megavitamin treatments are increasingly found in over the counter retail products and naturopathic textbooks.[citation needed]

A survey released in May, 2004 by the National Center for Complementary and Alternative Medicine focused on who used complementary and alternative medicine (CAM), what was used, and why it was used in the United States by adults age 18 years and over during 2002. The survey reported uses in the previous twelve months that include orthomolecular related uses: Nonvitamin, nonmineral, natural products 18.9%, Diet-based therapies 3.5%, Megavitamin therapy 2.8%.[10]

Another recent CAM survey reported that 12% of liver disease patients used the antioxidant silymarin, more than 6% used vitamins, and that "in all, 74% of patients reported using CAM in addition to the medications prescribed by their physician, but 26% did not inform their physician of their CAM use."[57] The use of high doses of vitamins is also common in people who have been diagnosed with cancer, although usage depends of the type of cancer and ranges from 26% to 35% among prostate cancer survivors up to 75% to 87% in breast cancer survivors.[11]

[edit] Mainstream medical and scientific reception

[edit] Methodology

Orthomolecular therapies have been criticized as lacking a sufficient evidence base for clinical use: their scientific foundations are too weak, the studies that have been performed are too few and too open to interpretation, and reported positive findings in observational studies are contradicted by the results of more rigorous clinical trials.[55][58] The lack of scientifically rigorous testing of orthomolecular medicine has led to its practices being classed with other forms of alternative medicine and regarded as unscientific.[59][60][61] It has been described as food faddism and quackery, with critics arguing that it is based upon an "exaggerated belief in the effects of nutrition upon health and disease."[15][16][17]

Proponents of orthomolecular medicine contend that, unlike some other forms of alternative medicine such as homeopathy, their ideas are at least biologically based, do not involve magical thinking,[62] and are capable of generating testable hypotheses.[63]

[edit] Views on safety and efficacy

Since its inception, the claims made by orthomolecular medicine have been rejected by mainstream medicine as unsubstantiated or false.[64] Organizations critical of orthomolecular claims include the American Cancer Society, the American Psychiatric Association, the National Institute of Mental Health,[53] the American Academy of Pediatrics,[65] CHAMPUS, and the Canadian Paediatric Society. The American Medical Association describes as "myths" the ideas that vitamin and mineral deficiencies are widespread, that the causes of most diseases are poor diets, or that most diseases can be prevented by nutritional supplements.[66]

Similarly, the American Cancer Society comments that the current scientific evidence does not "support use of orthomolecular therapy for most of the conditions for which it is promoted." Some supplements have exhibited benefits for specific conditions, while a few have been confirmed to be harmful; the consumption of nutritious foods is the best recognized method to obtain vitamins, minerals, and nutrients crucial for good health.[4] Barrie Cassileth, an adviser on alternative medicine to the National Institutes of Health, stated that "scientific research has found no benefit from orthomolecular therapy for any disease,"[55] and medical textbooks also report that there is "no evidence that megavitamin or orthomolecular therapy is effective in treating any disease."[67]

A 1973 task force of the American Psychiatric Association unanimously concluded:

This review and critique has carefully examined the literature produced by megavitamin proponents and by those who have attempted to replicate their basic and clinical work. It concludes in this regard that the credibility of the megavitamin proponents is low. Their credibility is further diminished by a consistent refusal over the past decade to perform controlled experiments and to report their new results in a scientifically acceptable fashion. Under these circumstances this Task Force considers the massive publicity which they promulgate via radio, the lay press and popular books, using catch phrases which are really misnomers like "megavitamin therapy" and "orthomolecular treatment," to be deplorable.[68]

The American Academy of Pediatrics labelled orthomolecular medicine a "cult" in 1976, in response to claims that orthomolecular medicine could cure childhood psychoses and learning disorders.[69]

Proponents of orthomolecular medicine counter that some vitamins and nutrients are now used in medicine as treatments for specific diseases, such as megadose niacin and fish oil for dyslipidemias, and megavitamin therapies for a group of rare inborn errors of metabolism.[24] A recent review in the Annals of Internal Medicine concluded that while some therapies might be beneficial, others might be harmful or interfere with effective medical therapy.[70] A recent study of over 161,000 individuals provided, in the words of the authors, "convincing evidence that multivitamin use has little or no influence on the risk of common cancers, cardiovascular disease, or total mortality in postmenopausal women."[12] A recent meta-analysis in JAMA suggested that supplementation with combinations of antioxidant vitamins (beta-carotene, vitamin A, and vitamin E) may increase mortality, although with respect to beta-carotene this conclusion may be due to the known harmful effect in smokers.[71]

[edit] Safety

In the United States, pharmaceuticals must be proven safe and effective to the satisfaction of the FDA before they can be marketed, whereas dietary supplements must be proven unsafe before regulatory action can be taken.[72] A number of orthomolecular US supplements are available in pharmaceutical versions that are sometimes quite similar in strength and general content, or in other countries are pharmaceuticals. The US regulations also have provisions to recognize a general level of safety for established nutrients that can forgo new drug safety tests. Proponents of orthomolecular medicine argue that supplements are less likely to cause dangerous side-effects or harm, since they are normally present in the body.[3]

Health professionals see orthomolecular medicine as encouraging individuals to dose themselves with large amounts of vitamins and other nutrients without conventional supervision, which they worry might be damaging to health. Potential risks[73] of megadose vitamins include an increased risk of coronary heart disease,[74] hypertension, thrombophlebitis, peripheral neuropathy, ataxia, neurological effects, liver toxicity, congenital abnormalities, spontaneous abortion, gouty arthritis, jaundice, kidney stones, and diarrhea.[75][76][77][78]

[edit] Example: use of vitamin E in orthomolecular medicine

Initial hopes for the usefulness of vitamin E in orthomolecular medicine were based on epidemiological studies suggesting that people who consumed more vitamin E had lower risks of chronic disease, such as coronary heart disease.[79] These observational studies could not distinguish between whether the higher levels of vitamin E improved health themselves, or whether confounding variables (such as other dietary factors or exercise) were responsible.[80][81] To distinguish between these possibilities, a number of randomized controlled trials were performed. Meta-analysis of these controlled clinical trials have not shown any clear benefit from any form of vitamin E supplementation for preventing chronic disease.[82][83][84][85] Further clinical studies show no benefit of vitamin E supplements for cardiovascular disease.[86]

Beyond the lack of apparent benefit, meta-analyses report that vitamin E supplementation is associated with an increased risk of death.[22][23] A 2005 meta-analysis found a consistent dose-dependent increase in mortality with increasing doses of vitamin E.[87] An increase in mortality was confirmed in a 2007 meta-analysis,[88] later repeated and extended by the same authors in the Cochrane Collaboration.[20]

[edit] Use in AIDS

Several orthomolecular related AIDS approaches such as multivitamins,[89] selenium[90] and amino acids[91] are used with reported improvements in patients, which are attributed to the placebo effect. High dose vitamin C treatments have long been used clinically to treat AIDS patients without any positive result.[92] Use of this orthomolecular treatment rather than current medical treatments such as antiretroviral drugs has been subject to criticism.[93]

An analysis of fifteen clinical trials of micronutrient therapies by the Cochrane Collaboration in 2005 found no evidence that such micronutrient approaches either reduce symptoms or mortality in HIV-infected adults who are not malnourished, but found evidence, in one hospital, that giving vitamin A to infants with HIV may be beneficial.[94] Vitamin A deficiency is found in children with HIV infection who may or may not have symptoms of AIDS. Vitamin A supplementation reduces morbidity and mortality in AIDS symptomatic children, but has no effect on asymptomatic children. It does not prevent HIV infection, cannot treat the chronic HIV infection, and will not cure AIDS.[95][96]

[edit] Deaths resulting from illegal vitamin trials in South Africa

Vitamin salesman Matthias Rath has been roundly criticised for presenting his supplements as a treatment for AIDS and testing them in illegal trials in South Africa. A former associate of Linus Pauling, Rath now promotes vitamins as a treatment for HIV infection, describing treatment with effective antiretroviral drugs as toxic and part of a global conspiracy serving the financial interests of the pharmaceutical industry.[93] In a lawsuit that found against Rath, the South African Medical Association blamed his vitamin products for several deaths,[97][98] the World Health Organization and two health agencies of the United Nations also described Rath’s advertisements as “wrong and misleading” and “an irresponsible attack on ARV (antiretroviral) therapy.”[99] Rath's trials, conducted with the aid of AIDS denialist David Rasnick, were declared unlawful; Rath, Rasnick and their foundation were barred from conducting further unauthorised clinical trials and from advertising their products.[100]

[edit] Conspiracy theories

Orthomolecularists, including Pauling, Hoffer and Ewan Cameron have alleged that their findings are actively suppressed by a conspiracy of mainstream medicine and the pharmaceutical industry. Hoffer wrote that "there is no conspiracy led and directed by a single person or by a single organization ... [h]owever, there is a conspiracy led and directed by a large number of professionals and their associations who have a common aim to protect their hard-earned orthodoxy, no matter what the cost to their opponent colleagues or to their patients".[101][102]

The Journal of Orthomolecular Medicine, founded in 1967 as the Journal of Schizophrenia, is the main publication of those involved in Orthomolecular Medicine. It was founded, as Abram Hoffer wrote, because of the alleged conspiracy: "We had to create our own journals because it was impossible to obtain entry into the official journals of psychiatry and medicine. Before 1967 I had not found it difficult to publish reports in these journals, and by then I had about 150 articles and several books in the establishment press."[103]

Mainstream medicine regards such claims of a conspiracy as unsubstantiated.[104][105] A review in the Journal of Clinical Oncology described such conspiracy theories, which allege collusion amongst physicians against unconventional and unproven treatments, as a common theme in many forms of alternative medicine.[106] Despite claims of conspiracy, the Linus Pauling Institute's funding comes primarily from the National Institutes of Health,[107] and several orthomolecular therapies have been officially sanctioned within Europe[108] and Japan.[109][110][111]

[edit] Additional supporters of orthomolecular medicine

[edit] See also

[edit] Citations

  1. ^ Hoffer A, Walker M (2000). Smart nutrients. Avery. ISBN 0895295628. 
  2. ^ a b Skinner Patricia (2004). "Gale encyclopedia of alternative medicine: holistic medicine". Thomson Gale. http://findarticles.com/p/articles/mi_g2603/is_0000/ai_2603000096. 
  3. ^ a b c "Definition of orthomolecular medicine". orthomed.org. http://www.orthomed.org/. Retrieved on June 2006. 
  4. ^ a b c d e "Orthomolecular medicine". Making treatment decisions. American Cancer Society. 2007-06-19. http://www.cancer.org/docroot/ETO/content/ETO_5_3X_Orthomolecular_Medicine.asp?sitearea=ETO. Retrieved on 2008-04-04. 
  5. ^ Nutrition Committee, Canadian Paediatric Society (November 1990). "Megavitamin and megamineral therapy in childhood". CMAJ 143 (10): 1009–13. PMID 1699646. 
  6. ^ a b c Pauling L (April 1968). "Orthomolecular psychiatry. Varying the concentrations of substances normally present in the human body may control mental disease". Science 160 (825): 265–71. doi:10.1126/science.160.3825.265. PMID 5641253. http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=5641253. 
  7. ^ Martínez ME, Marshall JR, Giovannucci E (2008). "Diet and cancer prevention: the roles of observation and experimentation" (PDF). Nature Reviews: Cancer 8 (9): 694–703. doi:10.1038/nrc2441. PMID 19143054. http://www.nature.com/nrc/journal/v8/n9/pdf/nrc2441.pdf. 
  8. ^ Baumel Syd (August 2000). Dealing with depression naturally : complementary and alternative therapies for restoring emotional health (2nd ed.). Los Angeles: McGraw-Hill. ISBN 0658002910. OCLC 43641423. 
  9. ^ a b Williams RJ (1998). Biochemical individuality: the basis for the genetotrophic concept (2nd ed.). New Canaan, Connecticut: Keats. ISBN 0879838930. OCLC 38239195. 
  10. ^ a b Barnes PM, Powell-Griner E, McFann K, Nahin RL (May 2004). "Complementary and alternative medicine use among adults: United States, 2002" (PDF). Adv Data (343): 1–19. PMID 15188733. http://www.cdc.gov/nchs/data/ad/ad343.pdf. 
  11. ^ a b Velicer CM, Ulrich CM (2008). "Vitamin and mineral supplement use among US adults after cancer diagnosis: a systematic review". J Clin Oncol 26 (4): 665–73. doi:10.1200/JCO.2007.13.5905. PMID 18235127. 
  12. ^ a b Neuhouser ML, Wassertheil-Smoller S, Thomson C, et al (February 2009). "Multivitamin use and risk of cancer and cardiovascular disease in the Women's Health Initiative cohorts". Arch Intern Med 169 (3): 294–304. doi:10.1001/archinternmed.2008.540. PMID 19204221. 
  13. ^ Aaronson S et al. (2003). "Cancer medicine". in Frei Emil, Kufe Donald W, Holland James F. Cancer medicine 6. Hamilton, Ontario: BC Decker. pp. 76. ISBN 1-55009-213-8. 
  14. ^ Nutrition Committee, Canadian Paediatric Society (1 January 1990). "Megavitamin and megamineral therapy in childhood". CMAJ 143 (10): 1009–13. PMID 1699646. 
  15. ^ a b Jarvis WT (1983). "Food faddism, cultism, and quackery". Annu Rev Nutr 3: 35–52. doi:10.1146/annurev.nu.03.070183.000343. PMID 6315036. 
  16. ^ a b Jukes TH (1990). "Nutrition science from vitamins to molecular biology". Annual Review of Nutrition 10 (1): 1–20. doi:10.1146/annurev.nu.10.070190.000245.  A short summary is in the journal's preface.
  17. ^ a b Braganza SF; Ozuah PO (2005). "Fad therapies". Pediatrics in Review 26 (10): 371–376. doi:10.1542/pir.26-10-371. PMID 16199591. 
  18. ^ "NIH state-of-the-science conference statement on multivitamin/mineral supplements and chronic disease prevention". NIH Consens State Sci Statements 23 (2): 1–30. 2006. PMID 17332802. 
  19. ^ Huang HY, Caballero B, Chang S, et al. (September 2006). "The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health state-of-the-science conference". Ann Intern Med 145 (5): 372–85. doi:10.1001/archinte.145.2.372. PMID 16880453. http://www.annals.org/cgi/pmidlookup?view=reprint&pmid=16880453. 
  20. ^ a b Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (2008). "Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases". Cochrane Database of Systematic Reviews (2): CD007176. doi:10.1002/14651858.CD007176. 
  21. ^ Satia JA, Littman A, Slatore CG, Galanko JA, White E (April 2009). "Long-term use of beta-carotene, retinol, lycopene, and lutein supplements and lung cancer risk: results from the VITamins And Lifestyle (VITAL) study". Am. J. Epidemiol. 169 (7): 815–28. doi:10.1093/aje/kwn409. PMID 19208726. 
  22. ^ a b Brody, Jane (March 23, 2009). "Extra Vitamin E: No Benefit, Maybe Harm". New York Times. http://www.nytimes.com/2009/03/24/health/24brod.html. Retrieved on March 24, 2009. 
  23. ^ a b "High dose vitamin E death warning". BBC. November 11, 2004. http://news.bbc.co.uk/1/hi/health/3998847.stm. Retrieved on March 24, 2009. 
  24. ^ a b c d e Menolascino FJ, Donaldson JY, Gallagher TF, Golden CJ, Wilson JE (1988). "Orthomolecular therapy: its history and applicability to psychiatric disorders". Child Psychiatry Hum Dev 18 (3): 133–50. doi:10.1007/BF00709727. PMID 2898324. 
  25. ^ "History of Orthomolecular Medicine". http://www.orthomolecular.org/history/index.shtml. 
  26. ^ AMA Council on Pharmacy and Chemistry (January 8, 1949). "Report of the council: cancer and the need for facts". JAMA 139: 93–98. 
  27. ^ "Evan Shute & Wilfrid Shute". Hall of Fame. Orthomolecular.org. http://orthomolecular.org/hof/ewshute.html. Retrieved on 2009-03-13. 
  28. ^ Mason SF (1997). "The science and humanism of Linus Pauling (1901–1994)". Chemical Society Reviews 26 (1): 29. doi:10.1039/cs9972600029. http://oregonstate.edu/dept/spc/subpages/ahp/overview/entirearticle.htm. Retrieved on 2009-02-16. 
  29. ^ Magner Lois N (2005). A history of medicine (Second ed.). Washington, DC: Taylor & Francis. ISBN 0824740742. OCLC 142979953. 
  30. ^ McCormick WJ (January 1951). "Vitamin C in the prophylaxis and therapy of infectious diseases". Arch Pediatr 68 (1): 1–9. PMID 14800557. 
  31. ^ Saul AW (2007). "Hidden in plain sight: the pioneering work of Frederick Robert Klenner, M.D.". J Orthomolecular Med 22 (1): 31–38. http://www.doctoryourself.com/klennerbio.html. Retrieved on 2009-02-16. 
  32. ^ Stone I (January 1967). "The genetic disease, Hypoascorbemia. A fresh approach to an ancient disease and some of its medical implications". Acta Genet Med Gemellol (Rome) 16 (1): 52–62. PMID 6063937. 
  33. ^ Chatterjee IB (December 1973). "Evolution and the Biosynthesis of Ascorbic Acid". Science 182 (4117): 1271–2. doi:10.1126/science.182.4118.1271. PMID 4752221. 
  34. ^ Hoffer A, Osmond H, Callbeck MJ, Kahan I (1957). "Treatment of schizophrenia with nicotinic acid and nicotinamide". J Clin Exp Psychopathol 18 (2): 131–58. PMID 13439009. 
  35. ^ Guyton JR (2007). "Niacin in cardiovascular prevention: mechanisms, efficacy, and safety". Curr Opin Lipidol 18 (4): 415–20. doi:10.1097/MOL.0b013e3282364add. PMID 17620858. 
  36. ^ Chen Q, Espey MG, Sun AY, et al (August 2008). "Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice". Proc Natl Acad Sci 105 (32): 11105–11109. doi:10.1073/pnas.0804226105. PMID 18678913. http://www.pnas.org/content/105/32/11105.full. 
  37. ^ Heaney ML, Gardner JR, Karasavvas N, et al (October 2008). "Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs". Cancer Res 68 (19): 8031–8. doi:10.1158/0008-5472.CAN-08-1490. PMID 18829561. Lay summary – New York Times (2008-10-01). 
  38. ^ Barrett, SJ (2001-05-05). "The dark side of Linus Pauling's legacy". Quackwatch. http://www.quackwatch.org/01QuackeryRelatedTopics/pauling.html. Retrieved on 2008-04-04. 
  39. ^ Kidd PM (September 2007). "Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids" (PDF). Altern Med Rev 12 (3): 207–27. PMID 18072818. 
  40. ^ a b Huemer RP (August 1977). "A theory of diagnosis for orthomolecular medicine". J. Theor. Biol. 67 (4): 625–35. doi:10.1016/0022-5193(77)90250-8. PMID 904336. http://linkinghub.elsevier.com/retrieve/pii/0022-5193(77)90250-8. Retrieved on 2009-03-02. 
  41. ^ Moyad Mark A (September 24, 2007). "Clinical data shows vitamin C may reduce risks of cancer, heart disease and variety of other health disorders". Genetic Engineering & Biotechnology News. 25–35. http://www.genengnews.com/news/bnitem.aspx?name=23587988. Retrieved on October 2007. 
  42. ^ Leung Lit-Hung (1997). "A stone that kills two birds: how pantothenic acid unveils the mysteries of acne vulgaris and obesity". J Orthomol Med 12 (2): 99-114. ISSN 0834-4825. OCLC 15726974. http://orthomolecular.org/library/jom/1997/articles/1997-v12n02-p099.shtml. 
  43. ^ Hoffer A, et al. (1 July 2005). "Treatment Protocol for Alcoholism". Orthomolecular Medicine News Service. http://www.orthomolecular.org/resources/omns/v01n06.shtml.  (self published)
  44. ^ Cameron Ewan, Pauling Linus (1976). "Supplemental ascorbate in the supportive treatment of cancer: prolongation of survival times in terminal human cancer". Proceeding of the National Academy of Sciences 73: 3685–9. doi:10.1073/pnas.73.10.3685. PMID 1068480.  (self published)
  45. ^ Cameron Ewan, Pauling Linus (1979). Cancer and vitamin C : a discussion of the nature, causes, prevention, and treatment of cancer with special reference to the value of vitamin C. New York: Norton. ISBN 0393500004. OCLC 5788147. 
  46. ^ Princeton Brain Bio Center. Brochure, distributed to patients. Skillman, New Jersey, 1983, The Center.
  47. ^ Plaza SW, Lamson DW. "Vitamin K2 in bone metabolism and osteoporosis". http://www.thorne.com/pdf/journal/10-1/vit_k10-1.pdf. 
  48. ^ Klenner FR (1971). "Observations on the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human pathology". J Appl Nutr 23: 61–88.  as reprinted with edits in Hoffer A, ed (1998). "Observations on the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human pathology" (PDF). J Orthomol Med 13 (4): 198-210. ISSN 0834-4825. OCLC 15726974. http://orthomolecular.org/library/jom/1998/pdf/1998-v13n04-p198.pdf.  (self published)
  49. ^ Reiter, PJ (1927). "Behandlung von Dementia Praecox mit metallsalzen. Mangan. Z". Neur 108: 464–80.  as cited in Pfeiffer, C; LaMola, S (1983). "Zinc and Manganese in the Schizophrenias". Journal of Orthomolecular Psychiatry 12 (3). 
  50. ^ Kay Lily E (1993). The molecular vision of life: Caltech, the Rockefeller Foundation, and the rise of the new biology. Oxford: Oxford University Press. ISBN 0195111435. 
  51. ^ Barney, Paul (1998). Doctor's guide to natural medicine. Pleasant Grove, Utah: Woodland. ISBN 1885670842. 
  52. ^ Edelman Eva (2001). Natural healing for schizophrenia: and other common mental disorders. Borage. ISBN 0965097676. 
  53. ^ a b Barrett, Stephen (2000-07-12). "Orthomolecular therapy". Quackwatch. http://www.quackwatch.org/01QuackeryRelatedTopics/ortho.html. Retrieved on 2008-01-02. 
  54. ^ Weston Price (2008) [Nutrition and Physical Degeneration],Price Pottenger Nutrition; Eight Edition edition . ISBN-10: 0916764206
  55. ^ a b c Cassileth Barrie R (1999). The alternative medicine handbook: the complete reference guide to alternative and complementary therapies. New York: W.W. Norton. pp. 67. ISBN 0393318168. OCLC 40880206. 
  56. ^ Wunderlich RC. "Orthomolecular Medicine Revisited". Orthomolecular Medicine Online. http://www.orthomed.org/wund.html. Retrieved on 2009-03-02. 
  57. ^ Strader DB, Bacon BR, Lindsay KL, et al (September 2002). "Use of complementary and alternative medicine in patients with liver disease". Am J Gastroenterol 97 (9): 2391–7. doi:10.1111/j.1572-0241.2002.05993.x. PMID 12358262. 
  58. ^ "Vitamin C for SARS?". Canadian Statistical Assessment Service. June 12, 2003. http://web.archive.org/web/20050925010741/http://www.canstats.org/readdetail.asp?id=542. 
  59. ^ Leibovici L (1999). "Alternative (complementary) medicine: a cuckoo in the nest of empiricist reed warblers". BMJ 319 (7225): 1629–32. PMID 10600974. 
  60. ^ Sampson W, Atwood K (2005). "Propagation of the Absurd: demarcation of the Absurd revisited" (PDF). Med J Aust 183 (11-12): 580–581. https://www.mja.com.au/public/issues/183_11_051205/sam10986_fm.pdf. 
  61. ^ Task Force on Complementary and Alternative Medicine (2000) (PDF), Report on complementary and alternative medicine, http://www.lrc.ky.gov/lrcpubs/Rm491.pdf 
  62. ^ Lindeman M, Keskivaara P, Roschier M (01 April 2000). "Assessment of magical beliefs about food and health". Journal of Health Psychology 5 (2): 195. http://hpq.sagepub.com/cgi/content/abstract/5/2/195. 
  63. ^ Jonas WB (1999), "Magic and methodology: when paradigms clash", The Journal of Alternative and Complementary Medicine 5 (4): 319–21, doi:10.1089/acm.1999.5.319, http://www.liebertonline.com/doi/abs/10.1089/acm.1999.5.319 
  64. ^ Miller M (1996). "Diet and psychological health". Altern Ther Health Med 2 (5): 40–8. PMID 8795935. 
  65. ^ Bennett, Forrest C. "Vitamin and mineral supplementation in Down's syndrome". http://pediatrics.aappublications.org/cgi/content/abstract/72/5/707. 
  66. ^ Council on Scientific Affairs (June 1997). "Report 12: Alternative medicine". American Medical Association. http://www.ama-assn.org/ama/no-index/about-ama/13638.shtml. Retrieved on 2009-02-18. 
  67. ^ Frei Emil, Kufe Donald W, Holland James F (2003). "20.76. Complementary and alternative cancer therapies". Cancer medicine 6. Hamilton, Ontario: BC Decker. pp. 76. ISBN 1550092138. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=orthomolecular&rid=cmed6.section.18479&WebEnv=0MnZPX94hO0XD2ugCELLkbhpkV5QLNBinRc8fAJ1IwDvCVoCzamY2zTpsFeeRiEdbTVTXzrZpQLqXt%40263F77C978AD3D40_0136SID&WebEnvRq=1#18482. Retrieved on 2008-04-04. 
  68. ^ Lipton M, et al. (1973), Task force report on megavitamin and orthomolecular therapy in psychiatry, Washington DC: American Psychiatric Association ; as cited in Barrett, Stephen (2000-07-12). "Orthomolecular Therapy". Quackwatch. http://www.quackwatch.org/01QuackeryRelatedTopics/ortho.html. Retrieved on 2008-01-02. 
  69. ^ American Academy of Pediatrics Committee on Nutrition (1976). "Megavitamin therapy for childhood psychoses and learning disabilities". Pediatrics 58 (6): 910–2. PMID 995522. 
  70. ^ Eisenberg DM, Cohen MH, Hrbek A, Grayzel J, Van Rompay MI, Cooper RA (December 2002). "Credentialing complementary and alternative medical providers". Ann Intern Med 137 (12): 965–73. PMID 12484712. 
  71. ^ Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C (2007). "Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis". JAMA 297 (8): 842–57. doi:10.1001/jama.297.8.842. PMID 17327526.  See also the letter to JAMA by Philip Taylor and Sanford Dawsey and the reply by the authors of the original paper.
  72. ^ "Dietary Supplement Health and Education Act of 1994". Food and Drug Administration. 1994-10-25. http://www.fda.gov/opacom/laws/dshea.html. Retrieved on 2008-04-04. 
  73. ^ Rosenbloom, M (2007-12-12). "Toxicity, vitamin". eMedicine. http://www.emedicine.com/emerg/topic638.htm. Retrieved on 2008-04-04. 
  74. ^ Rapola JM, Virtamo J, Ripatti S, et al (1997). "Randomised trial of alpha-tocopherol and beta-carotene supplements on incidence of major coronary events in men with previous myocardial infarction". Lancet 349 (9067): 1715–20. doi:10.1016/S0140-6736(97)01234-8. PMID 9193380. 
  75. ^ Arroyave G (1988). "[Abuse of megadoses of vitamins]" (in Spanish; Castilian). Arch Latinoam Nutr 38 (3): 589–98. PMID 3153129. 
  76. ^ Blair KA (1986). "Vitamin supplementation and megadoses". Nurse Pract 11 (7): 19–26, 31–6. doi:10.1097/00006205-198607000-00003. PMID 3737019. 
  77. ^ Roberts HJ (1995). "Vitamin E". Lancet 345 (8951): 737. doi:10.1016/S0140-6736(95)90913-3. PMID 7885163. 
  78. ^ Bégin M, Kaegi E (1999). "Unconventional therapies and cancer" (PDF). CMAJ 161 (6): 686–7. PMID 10513271. http://www.cmaj.ca/cgi/reprint/161/6/686. 
  79. ^ Traber MG (November 2006). "How much vitamin E? ... Just enough!". Am J Clin Nutr 84 (5): 959–60. PMID 17093143. 
  80. ^ Gaziano JM (December 2004). "Vitamin E and cardiovascular disease: observational studies". Ann N Y Acad Sci 1031: 280–91. doi:10.1196/annals.1331.028. PMID 15753154. 
  81. ^ Hemilä H, Miller ER (01 July 2007). "Evidence-based medicine and vitamin E supplementation". Am J Clin Nutr 86 (1): 261–2; author reply 262–4. PMID 17616790. http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=17616790. 
  82. ^ Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ (2003). "Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials". Lancet 361 (9374): 2017–23. doi:10.1016/S0140-6736(03)13637-9. PMID 12814711. 
  83. ^ Stocker R (2007). "Vitamin E". Novartis Found Symp 282: 77–87; discussion 87–92, 212–8. doi:10.1002/9780470319444.ch6. PMID 17913225. 
  84. ^ Cherubini A, Vigna GB, Zuliani G, Ruggiero C, Senin U, Fellin R (2005). "Role of antioxidants in atherosclerosis: epidemiological and clinical update". Curr Pharm Des 11 (16): 2017–32. doi:10.2174/1381612054065783. PMID 15974956. 
  85. ^ Kline K, Lawson KA, Yu W, Sanders BG (2007). "Vitamin E and cancer". Vitam Horm 76: 435–61. doi:10.1016/S0083-6729(07)76017-X. PMID 17628185. 
  86. ^ Sesso HD, Buring JE, Christen WG, et al (November 2008). "Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomized controlled trial". JAMA 300 (18): 2123–33. doi:10.1001/jama.2008.600. PMID 18997197. 
  87. ^ Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E (2005). "Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality". Ann Intern Med 142 (1): 37–46. PMID 15537682. http://www.annals.org/cgi/reprint/142/1/37. 
  88. ^ Bjelakovic G, Nikolova D, Gluud L, Simonetti R, Gluud C (2007). "Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis". JAMA 297 (8): 842–57. doi:10.1001/jama.297.8.842. PMID 17327526. http://jama.ama-assn.org/cgi/content/abstract/297/8/842. 
  89. ^ Abrams B, Duncan D, Hertz-Picciotto I (August 1993). "A prospective study of dietary intake and acquired immune deficiency syndrome in HIV-seropositive homosexual men". J Acquir Immune Defic Syndr 6 (8): 949–58. PMID 8100273. 
  90. ^ Patrick Lyn (December 1999). "Nutrients and HIV: part one -- beta carotene and selenium" (PDF). Altern Med Rev 4 (6): 403–13. PMID 10608913. http://www.thorne.com/altmedrev/.fulltext/4/6/403.pdf. Retrieved on 2008-08-25. 
  91. ^ Lichtenstein BS (1995). "Nutrition and HIV". STEP Perspect 7 (1): 2–5. PMID 11362399. 
  92. ^ Batterham M, Gold J, Naidoo D, et al (February 2001). "A preliminary open label dose comparison using an antioxidant regimen to determine the effect on viral load and oxidative stress in men with HIV/AIDS". Eur J Clin Nutr 55 (2): 107–14. doi:10.1038/sj.ejcn.1601124. PMID 11305623. 
  93. ^ a b Boseley Sarah (May 14, 2005). "Discredited doctor's 'cure' for Aids ignites life-and-death struggle in South Africa". Manchester: The Guardian. http://www.guardian.co.uk/world/2005/may/14/southafrica.internationalaidanddevelopment. 
    *Smith TC, Novella SP (August 2007). "HIV denial in the Internet era". PLoS Med 4 (8): e256. doi:10.1371/journal.pmed.0040256. PMID 17713982. 
    *"Apartheid a pharmaceutical plot - Rath". Cape Town: Independent Online. May 10, 2007. http://www.int.iol.co.za/index.php?set_id=1&click_id=6&art_id=nw20070510150555640C886929. 
  94. ^ Irlam JH, Visser ME, Rollins N, Siegfried N (2005). "Micronutrient supplementation in children and adults with HIV infection". Cochrane Database Syst Rev (4): CD003650. doi:10.1002/14651858.CD003650.pub2. PMID 16235333. 
  95. ^ Grotto I, Mimouni M, Gdalevich M, Mimouni D (March 2003). "Vitamin A supplementation and childhood morbidity from diarrhea and respiratory infections: a meta-analysis". J Pediatr 142 (3): 297–304. doi:10.1067/mpd.2003.116. PMID 12640379. 
  96. ^ Mehta Saurabh, Fawzi Wafaie (2007). "Effects of vitamins, including vitamin A, on HIV/AIDS patients". Vitam Horm 75: 355–83. doi:10.1016/S0083-6729(06)75013-0. PMID 17368322. 
  97. ^ Watson J (January 2006). "Scientists, activists sue South Africa's AIDS 'denialists'". Nat Med 12 (1): 6. doi:10.1038/nm0106-6a. PMID 16397537. 
  98. ^ "TAC hails ruling on Rath". Cape Town: Independent Online. June 13, 2008. http://www.iol.co.za/index.php?set_id=1&click_id=15&art_id=nw20080613124210476C691501. 
  99. ^ Reed John (July 25, 2005). "HIV fight focuses on ads". Los Angeles Times. http://articles.latimes.com/2005/jul/25/business/ft-aids25. 
  100. ^ "South African court bans AIDS vitamin trials". Reuters. June 13, 2008. http://africa.reuters.com/top/news/usnBAN351191.html. Retrieved on June 20, 2008. 
  101. ^ Hoffer A (1987). "Is there a conspiracy?" (PDF). J Orthomol Med 2 (3): 158. http://www.orthomolecular.org/library/jom/1987/pdf/1987-v02n03-p158.pdf. 
  102. ^ Thomas Hager (1995). Force of nature: the life of Linus Pauling. New York: Simon & Schuster. ISBN 0684809095. 
  103. ^ Hoffer Abram. "History". J Orthomol Med. http://www.orthomed.org/jom/jomhist.htm. 
  104. ^ Razzouk N, Seitz V (2003), "Marketing to the heart: a practical approach to dealing with health care quackery" (PDF), Clinical Research and Regulatory Affairs 20 (4): 469–478, doi:10.1081/CRP-120026128, http://www.informaworld.com/index/713622947.pdf 
  105. ^ Weitzman S (1998). "Alternative nutritional cancer therapies". Int J Cancer Suppl 11: 69–72. doi:10.1002/(SICI)1097-0215(1998)78:11 (inactive 2009-03-14). PMID 9876483. 
  106. ^ Gertz MA, Bauer BA (May 2003). "Caring (really) for patients who use alternative therapies for cancer". J Clin Oncol 21 (9 Suppl): 125s–128s. doi:10.1200/JCO.2003.01.195. PMID 12743218. 
  107. ^ Frei, Balz (June 2006). "From the Director". LPI Research Newsletter. Linus Pauling Institute. http://lpi.oregonstate.edu/ss06/director.html. 
  108. ^ Hydro Pronova (11 December 2001). OMACOR deal signed with new Euro partners. Press release. http://www.hydro.com/en/Press-room/News/Archive/2001/December/16080/. Retrieved on 2009-03-13. 
  109. ^ Sumi H, Hamada H, Nakanishi K, Hiratani H (1990). "Enhancement of the fibrinolytic activity in plasma by oral administration of nattokinase". Acta Haematol 84 (3): 139–43. doi:10.1159/000205051. PMID 2123064. 
  110. ^ Bonakdar RA, Guarneri E (15 September 2005). "Coenzyme Q10". Am Fam Physician 72 (6): 1065-70. PMID 16190504. http://www.aafp.org/afp/20050915/1065.html.  prescribed for CHF in Japan since 1974, AAFP
  111. ^ Kaitin KI, Brown J (1995). "A drug lag update". Drug Information Journal 29: 361–73. 

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