Phylogenetics
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In biology, phylogenetics is the study of evolutionary relatedness among various groups of organisms (e.g., species, populations), which is discovered through molecular sequencing data and morphological data matrices. The term phylogenetics is of Greek origin from the terms phyle/phylon (φυλή/φῦλον), meaning "tribe, race," and genetikos (γενετικός), meaning "relative to birth" from genesis (γένεσις, "birth"). Taxonomy, the classification of organisms according to similarity, has been richly informed by phylogenetics but remains methodologically and logically distinct.[1] The fields overlap however in the science of phylogenetic systematics or cladism, where only phylogenetic trees are used to delimit taxa, each representing a group of lineage-connected individuals[2].
Evolution is regarded as a branching process, whereby populations are altered over time and may speciate into separate branches, hybridize together, or terminate by extinction. This may be visualized as a multidimensional character-space that a population moves through over time. The problem posed by phylogenetics is that genetic data are only available for the present, and fossil records (osteometric data) are sporadic and less reliable. Our knowledge of how evolution operates is used to reconstruct the full tree.[3]
There are some terms that describe the nature of a grouping in such trees. For instance, all birds and reptiles are believed to have descended from a single common ancestor, so this taxonomic grouping (yellow in the diagram below) is called monophyletic. "Modern reptile" (cyan in the diagram) is a grouping that contains a common ancestor, but does not contain all descendents of that ancestor (birds are excluded). This is an example of a paraphyletic group. A grouping such as warm-blooded animals would include only mammals and birds (red/orange in the diagram) and is called polyphyletic because the members of this grouping do not include the most recent common ancestor. Thus, a phylogenetic tree is based on a hypothesis of the order in which evolutionary events are assumed to have occurred. [4] Cladistics is the current method of choice to infer phylogenetic trees. The most commonly-used methods to infer phylogenies include parsimony, maximum likelihood, and MCMC-based Bayesian inference. Phenetics, popular in the mid-20th century but now largely obsolete, uses distance matrix-based methods to construct trees based on overall similarity, which is often assumed to approximate phylogenetic relationships. All methods depend upon an implicit or explicit mathematical model describing the evolution of characters observed in the species included, and are usually used for molecular phylogeny, wherein the characters are aligned nucleotide or amino acid sequences.
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[edit] Molecular phylogenetics
The evolutionary connections between organisms are represented graphically through phylogenetic trees. Due to the fact that evolution takes place over long periods of time that cannot be observed directly, biologists must continuously reconstruct phylogenies by inferring the evolutionary relationships among present-day organisms. Fossils can aid with the reconstruction of phylogenies; however, fossil records are often too poor to be of good help. Therefore, biologists tend to be restricted with analysing present-day organisms to identify their evolutionary relationships. Phylogenetic relationships in the past were reconstructed by looking at phenotypes, often anatomical characteristics. Today, molecular data, which includes protein and DNA sequences, are used to construct phylogenetic trees.[5]
[edit] Ernst Haeckel's recapitulation theory
During the late 19th century, Ernst Haeckel's recapitulation theory, or biogenetic law, was widely accepted. This theory was often expressed as "ontogeny recapitulates phylogeny", i.e. the development of an organism exactly mirrors the evolutionary development of the species. Haeckel's early version of this hypothesis [that the embryo mirrors adult evolutionary ancestors] has since been rejected, and the hypothesis amended as the embryo's development mirroring embryos of its evolutionary ancestors. Most modern biologists recognize numerous connections between ontogeny and phylogeny, explain them using evolutionary theory, or view them as supporting evidence for that theory. Donald Williamson suggested that larvae and embryos represented adults in other taxa that have been transferred by hybridization (the larval transfer theory).[6][7]
[edit] Gene transfer
In general, organisms can inherit genes in two ways: vertical gene transfer and horizontal gene transfer. Vertical gene transfer is the passage of genes from parent to offspring, and horizontal gene transfer or lateral gene transfer occurs when genes jump between unrelated organisms, a common phenomenon in prokaryotes.
Lateral gene transfer has complicated the determination of phylogenies of organisms, since inconsistencies have been reported depending on the gene chosen.
Carl Woese came up with the three-domain theory of life (eubacteria, archaea and eukaryotes) based on his discovery that the genes encoding ribosomal RNA are ancient and distributed over all lineages of life with little or no lateral gene transfer. Therefore rRNA are commonly recommended as molecular clocks for reconstructing phylogenies.
This has been particularly useful for the phylogeny of microorganisms, to which the species concept does not apply and which are too morphologically simple to be classified based on phenotypic traits.
[edit] Taxon sampling and phylogenetic signal
Owing to the development of advanced sequencing techniques in molecular biology, it has become feasible to gather large amounts of data (DNA or amino acid sequences) to estimate phylogenies. For example, it is not rare to find studies with character matrices based on whole mitochondrial genomes. However, it has been proposed that it is more important to increase the number of taxa in the matrix than to increase the number of characters, because the more taxa the more robust is the resulting phylogeny. This is partly due to the breaking up of long branches. It has been argued that this is an important reason to incorporate data from fossils into phylogenies where possible. Using simulations, Derrick Zwickl and Hillis[8] found that increasing taxon sampling in phylogenetic inference has a positive effect on the accuracy of phylogenetic analyses.
Another important factor that affects the accuracy of tree reconstruction is whether the data analyzed actually contain a useful phylogenetic signal, a term that is used generally to denote whether related organisms tend to resemble each other with respect to their genetic material or phenotypic traits.[9]
[edit] See also
- Bauplan
- Bioinformatics
- Biomathematics
- Cladistics
- Coalescent theory
- Computational phylogenetics
- EDGE of Existence Programme
- Important publications in phylogenetics
- Language family
- Maximum parsimony
- Molecular phylogeny
- PhyloCode
- Joe Felsenstein
- Systematics
- Phylogenetic tree
- Phylogenetic network
- Phylogenetic nomenclature
- Phylogenetics software
- Phylogenetic tree viewers
- Phylogeography
- Phylogenetic comparative methods
[edit] References
- ^ Edwards AWF, Cavalli-Sforza LL Phylogenetics is that branch of life science,which deals with the study of evolutionary relation among various groups of organisms,through molecular sequencing data. (1964). Systematics Assoc. Publ. No. 6: Phenetic and Phylogenetic Classification. ed. Reconstruction of evolutionary trees. pp. 67–76.
- ^ Speer, Vrian (1998). "UCMP Glossary: Phylogenetics". UC Berkeley. http://www.ucmp.berkeley.edu/glossary/glossary_1.html. Retrieved on 2008-03-22.
- ^ Cavalli-Sforza LL, Edwards AWF (Sep., 1967). "Phylogenetic analysis: Models and estimation procedures". Evol. 21 (3): 550–570. doi:. http://links.jstor.org/sici?sici=0014-3820%28196709%2921%3A3%3C550%3APAMAEP%3E2.0.CO%3B2-I.
- ^ Y-DNA HAPLOGROUP TREE. 2002. http://www.familytreedna.com/haplotree.html
- ^ Pierce, Benjamin A. (2007-12-17). Genetics: A conceptual Approach (3rd ed. ed.). W. H. Freeman. ISBN 978-0716-77928-5.
- ^ Williamson DI (2003-12-31). "xviii". The Origins of Larvae (2nd ed. ed.). Springer. pp. 261. ISBN 978-1402-01514-4.
- ^ Williamson DI (2006). "Hybridization in the evolution of animal form and life-cycle". Zoological Journal of the Linnean Society 148: 585–602.
- ^ Zwickl DJ, Hillis DM (2002). "Increased taxon sampling greatly reduces phylogenetic error". Systematic Biology 51: 588–598. doi:.
- ^ Blomberg SP, Garland T Jr, Ives AR (2003). "Testing for phylogenetic signal in comparative data: behavioral traits are more labile". Evolution 57: 717–745.
[edit] External links
- The Tree of Life
- Interactive Tree of Life
- PhyloCode
- UCMP Exhibit Halls: Phylogeny Wing
- Willi Hennig Society
- Filogenetica.org in Spanish
- PhyloPat, Phylogenetic Patterns
- Phylogenetic inferring on the T-REX server
- Mesquite
- NCBI - Systematics and Molecular Phylogenetics
- What Genomes Can Tell Us About the Past - lecture on phylogenetics by Sydney Brenner
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